PUBLICATION
Netrins Promote Developmental and Therapeutic Angiogenesis
- Authors
- Wilson, B.D., Ii, M., Park, K.W., Suli, A., Sorensen, L.K., Larrieu-Lahargue, F., Urness, L.D., Suh, W., Asai, J., Kock, G.A., Thorne, T., Silver, M., Thomas, K.R., Chien, C.B., Losordo, D.W., and Li, D.Y.
- ID
- ZDB-PUB-060703-18
- Date
- 2006
- Source
- Science (New York, N.Y.) 313(5787): 640-644 (Journal)
- Registered Authors
- Chien, Chi-Bin, Suli, Arminda
- Keywords
- none
- MeSH Terms
-
- Endothelial Cells/physiology*
- DNA, Complementary
- Mice
- Cell Movement
- Embryo, Nonmammalian
- Receptors, Cell Surface/physiology
- Zebrafish
- Diabetic Angiopathies/therapy
- Tumor Suppressor Proteins/genetics
- Tumor Suppressor Proteins/pharmacology
- Tumor Suppressor Proteins/physiology*
- Animals
- Muscle, Skeletal/blood supply
- Ischemia/drug therapy
- Diabetic Neuropathies/therapy
- Neural Conduction
- Humans
- Neovascularization, Physiologic*
- Vascular Endothelial Growth Factor A/therapeutic use
- Genetic Therapy
- Angiogenesis Inducing Agents
- Cell Line
- Chemotaxis
- Nerve Growth Factors/genetics
- Nerve Growth Factors/pharmacology
- Nerve Growth Factors/physiology*
- Endothelium, Vascular/cytology
- PubMed
- 16809490 Full text @ Science
Citation
Wilson, B.D., Ii, M., Park, K.W., Suli, A., Sorensen, L.K., Larrieu-Lahargue, F., Urness, L.D., Suh, W., Asai, J., Kock, G.A., Thorne, T., Silver, M., Thomas, K.R., Chien, C.B., Losordo, D.W., and Li, D.Y. (2006) Netrins Promote Developmental and Therapeutic Angiogenesis. Science (New York, N.Y.). 313(5787):640-644.
Abstract
Axonal guidance and vascular patterning share several guidance cues, including proteins of the netrin family. We demonstrate that netrins stimulate the proliferation, migration and tube formation of human endothelial cells in vitro, and that this stimulation is independent of known netrin receptors. Knockdown of netrin1a mRNA in zebrafish inhibits vascular sprouting, implying a pro-angiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping