PUBLICATION
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish
- Authors
- Panagos, P.G., Dobrinski, K.P., Chen, X., Grant, A.W., Traver, D., Djeu, J.Y., Wei, S., and Yoder, J.A.
- ID
- ZDB-PUB-060213-3
- Date
- 2006
- Source
- Immunogenetics 58(1): 31-40 (Journal)
- Registered Authors
- Dobrinski, Kim P., Grant, Amanda W., Traver, David, Yoder, Jeffrey A.
- Keywords
- C-type lectin, ITIM, Natural killer cells, Signaling motifs
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Cell Survival/physiology
- Chromosomes*
- Chromosomes, Artificial, Bacterial
- Killer Cells, Natural/metabolism
- Lectins, C-Type/chemistry
- Lectins, C-Type/genetics*
- Lectins, C-Type/metabolism
- Lectins, C-Type/physiology
- Lymphocytes/metabolism*
- Models, Molecular
- Molecular Sequence Data
- Myeloid Cells/metabolism*
- Phylogeny
- Zebrafish/genetics*
- Zebrafish/immunology
- Zebrafish/metabolism
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism*
- PubMed
- 16467987 Full text @ Immunogenetics
Citation
Panagos, P.G., Dobrinski, K.P., Chen, X., Grant, A.W., Traver, D., Djeu, J.Y., Wei, S., and Yoder, J.A. (2006) Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish. Immunogenetics. 58(1):31-40.
Abstract
The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping