PUBLICATION
GDNF family ligand immunoreactivity in the gut of teleostean fish
- Authors
- Lucini, C., Maruccio, L., Tafuri, S., Bevaqua, M., Staiano, N., and Castaldo, L.
- ID
- ZDB-PUB-050930-11
- Date
- 2005
- Source
- Anatomy and embryology 210(4): 265-274 (Journal)
- Registered Authors
- Keywords
- Intestine, Fish, Neurotrophic factors, Innervation, Endocrine cells
- MeSH Terms
-
- Animals
- Bass
- Digestive System/chemistry
- Digestive System/innervation*
- Digestive System/metabolism
- Enteric Nervous System/chemistry
- Enteric Nervous System/metabolism*
- Fishes/metabolism*
- Glial Cell Line-Derived Neurotrophic Factors/analysis*
- Neurturin/analysis
- Sea Bream
- Trout
- PubMed
- 16193278 Full text @ Anat. Embryol.
Citation
Lucini, C., Maruccio, L., Tafuri, S., Bevaqua, M., Staiano, N., and Castaldo, L. (2005) GDNF family ligand immunoreactivity in the gut of teleostean fish. Anatomy and embryology. 210(4):265-274.
Abstract
Glial-derived neurotrophic factor (GDNF), neurturin (NRTN), persephin (PSPN), and artemin (ARTN) are a group of proteins belonging to the GDNF family ligands (GFLs). GDNF, NRTN, and ARTN support the survival of central, peripheral, and autonomic neuron populations, while PSPN supports the survival of only several central neuron populations. A common receptor, RET, modulates the action of this family and a co-receptor, GFRalpha, determines RET ligand specificity. GDNF and NRTN appear to be essential for enteric nervous system (ENS) development in mammals, zebrafish, and other teleostean species. GFLs are also essential for the maintenance and plasticity of adult mammalian ENS. In this study, the distribution pattern of GFLs in the intestine of five adult fish (bass, gilt-head, scorpionfish, trout, and zebrafish) was evaluated by immunochemical and immunocytochemical analysis. The results demonstrated the presence of GDNF, NRTN, and ARTN in the gut of all species studied. They appeared to be spread in the ENS and/or endocrine cells of the intestine. These findings suggest that the presence of GFLs in fish gut is not only limited to developmental period, but could be also involved in the enteric physiology of adult species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping