PUBLICATION
Cloning and characterization of a full-length pronociceptin in zebrafish: evidence of the existence of two different nociceptin sequences in the same precursor
- Authors
- Gonzalez-Nuñez, V., Gonzalez-Sarmiento, R., and Rodriguez, R.E.
- ID
- ZDB-PUB-031009-8
- Date
- 2003
- Source
- BBA Gene Structure and Expression 1629(1-3): 114-118 (Journal)
- Registered Authors
- González Nuñez, Veronica, Rodriguez, Raquel E.
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Brain/metabolism
- Cloning, Molecular
- Intestines/metabolism
- Molecular Sequence Data
- Opioid Peptides/genetics*
- Protein Precursors/genetics*
- Receptors, Opioid/genetics*
- Sequence Alignment
- Zebrafish/genetics*
- PubMed
- 14522087 Full text @ BBA Gene Structure and Expression
Citation
Gonzalez-Nuñez, V., Gonzalez-Sarmiento, R., and Rodriguez, R.E. (2003) Cloning and characterization of a full-length pronociceptin in zebrafish: evidence of the existence of two different nociceptin sequences in the same precursor. BBA Gene Structure and Expression. 1629(1-3):114-118.
Abstract
We report the cloning and molecular characterization of a zebrafish pronociceptin gene, which is expressed in brain and intestine. This fish precursor codes for two different nociceptin peptides, one of which presents an opioid sequence in its N-terminus, being more similar to dynorphin A than its mammalian counterparts. Our results represent a new tool to investigate the function of nociceptin and its receptor in relation to pain and drug addiction.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping