PUBLICATION

Reptin and pontin antagonistically regulate heart growth in zebrafish embryos

Authors
Rottbauer, W., Saurin, A.J., Lickert, H., Shen, X., Burns, C.G., Wo, Z.G., Kemler, R., Kingston, R., Wu, C., and Fishman, M.
ID
ZDB-PUB-021204-1
Date
2002
Source
Cell   111(5): 661-672 (Journal)
Registered Authors
Fishman, Mark C., Rottbauer, Wolfgang
Keywords
none
MeSH Terms
  • Nuclear Proteins/genetics
  • Nuclear Proteins/physiology*
  • Serine Endopeptidases/physiology
  • Adenosine Triphosphatases/chemistry
  • Adenosine Triphosphatases/physiology
  • Myocardium/cytology
  • Myocardium/ultrastructure
  • Gene Expression Regulation, Developmental
  • Heat-Shock Proteins/physiology
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
  • Enzyme Activation
  • Animals
  • beta Catenin
  • Amino Acid Sequence
  • Sequence Homology, Amino Acid
  • Cell Division
  • Zebrafish
  • ATP-Dependent Proteases
  • Embryo, Nonmammalian
  • Heart/embryology*
  • Conserved Sequence
  • Carrier Proteins
  • Point Mutation
  • Base Sequence
  • Cytoskeletal Proteins/physiology
  • Cardiomegaly/embryology
  • Cardiomegaly/etiology
  • Cardiomegaly/genetics
  • Molecular Sequence Data
  • Trans-Activators/physiology
PubMed
12464178 Full text @ Cell
Abstract
Organ size is precisely regulated during development, but the control mechanisms remain obscure. We have isolated a mutation in zebrafish, liebeskummer (lik), which causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. The mutation activates ATPase activity of Reptin complexes and causes a cell-autonomous proliferation of cardiomyocytes to begin well after progenitors have fashioned the primitive heart tube. With regard to heart growth, beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. Pontin reduction phenocopies the cardiac hyperplasia of the lik mutation. Thus, the Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping