PUBLICATION
Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2
- Authors
- Groth, C., Nornes, S., McCarty, R., Tamme, R., and Lardelli, M.
- ID
- ZDB-PUB-021112-3
- Date
- 2002
- Source
- Development genes and evolution 212(10): 486-490 (Journal)
- Registered Authors
- Groth, Casper, Lardelli, Michael, McCarty, Rosa, Nornes, Svanhild, Tamme, Richard
- Keywords
- Alzheimer's disease; presenilin; neural crest; melanocyte; zebrafish
- MeSH Terms
-
- Alzheimer Disease/genetics
- Amino Acid Sequence
- Animals
- Blotting, Western
- Gene Expression Regulation, Developmental*
- Humans
- Melanocytes/cytology
- Melanocytes/physiology*
- Membrane Proteins/genetics*
- Membrane Proteins/isolation & purification
- Molecular Sequence Data
- Neural Crest
- Phylogeny
- Presenilin-2
- Sequence Homology, Amino Acid
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/growth & development
- PubMed
- 12424519 Full text @ Dev. Genes Evol.
Citation
Groth, C., Nornes, S., McCarty, R., Tamme, R., and Lardelli, M. (2002) Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Development genes and evolution. 212(10):486-490.
Abstract
Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue ( pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping