PUBLICATION
Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling
- Authors
- Houart, C., Caneparo, L., Heisenberg, C.P., Barth, K.A., Take-uchi, M., and Wilson, S.W.
- ID
- ZDB-PUB-021017-71
- Date
- 2002
- Source
- Neuron 35(2): 255-265 (Journal)
- Registered Authors
- Barth, Anukampa, Caneparo, Luca, Heisenberg, Carl-Philipp, Houart, Corinne, Take-uchi, Masaya, Wilson, Steve
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning/genetics*
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins/genetics
- Bone Morphogenetic Proteins/metabolism
- Cell Differentiation/genetics
- Cell Lineage/genetics
- Cytoskeletal Proteins
- Denervation
- Gastrula/cytology
- Gastrula/metabolism*
- Gene Expression Regulation/physiology*
- Immunohistochemistry
- Mesencephalon/cytology
- Mesencephalon/embryology
- Mesencephalon/metabolism
- Molecular Sequence Data
- Mutation/genetics
- Neurons/cytology
- Neurons/metabolism
- Phylogeny
- Prosencephalon/cytology
- Prosencephalon/embryology
- Prosencephalon/metabolism
- Proteins/genetics
- Proteins/isolation & purification*
- Proteins/metabolism
- Proto-Oncogene Proteins/genetics
- Proto-Oncogene Proteins/metabolism*
- Signal Transduction/genetics
- Telencephalon/cytology
- Telencephalon/embryology*
- Telencephalon/metabolism
- Transforming Growth Factor beta*
- Wnt Proteins
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/isolation & purification*
- PubMed
- 12160744 Full text @ Neuron
Citation
Houart, C., Caneparo, L., Heisenberg, C.P., Barth, K.A., Take-uchi, M., and Wilson, S.W. (2002) Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2):255-265.
Abstract
Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tlc, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tlc. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping