PUBLICATION
Migration and function of a glial subtype in the vertebrate peripheral nervous system
- Authors
- Gilmour, D.T., Maischein, H.M., Nüsslein-Volhard, C.
- ID
- ZDB-PUB-020624-1
- Date
- 2002
- Source
- Neuron 34(4): 577-588 (Journal)
- Registered Authors
- Gilmour, Darren, Maischein, Hans-Martin, Nüsslein-Volhard, Christiane
- Keywords
- none
- MeSH Terms
-
- Indicators and Reagents/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Growth Cones/metabolism*
- Growth Cones/ultrastructure
- Neuroglia/cytology
- Neuroglia/metabolism*
- Cell Differentiation/genetics*
- Neural Crest/cytology
- Neural Crest/embryology*
- Neural Crest/metabolism
- Peripheral Nervous System/cytology
- Peripheral Nervous System/embryology*
- Peripheral Nervous System/metabolism
- Gene Expression Regulation, Developmental/genetics
- Cell Movement/genetics*
- High Mobility Group Proteins/genetics
- High Mobility Group Proteins/metabolism
- Peripheral Nerves/abnormalities
- Peripheral Nerves/cytology
- Peripheral Nerves/metabolism
- Transcription Factors
- Cues
- SOXE Transcription Factors
- Animals
- Cell Communication/genetics*
- Luminescent Proteins/metabolism
- Repressor Proteins/genetics
- Repressor Proteins/metabolism
- Green Fluorescent Proteins
- Embryo, Nonmammalian
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- Stem Cells/cytology
- Stem Cells/metabolism
- Animals, Genetically Modified
- PubMed
- 12062041 Full text @ Neuron
Citation
Gilmour, D.T., Maischein, H.M., Nüsslein-Volhard, C. (2002) Migration and function of a glial subtype in the vertebrate peripheral nervous system. Neuron. 34(4):577-588.
Abstract
Glia-axon interactions are essential for the development and function of the nervous system. We combine in vivo imaging and genetics to address the mechanism by which the migration of these cells is coordinated during embryonic development. Using stable transgenic lines, we have followed the migration of one subset of glial cells and their target axons in living zebrafish embryos. These cells coalesce at an early stage and remain coupled throughout migration, with axons apparently pathfinding for glia. Mutant analysis demonstrates that axons provide instructive cues that are sufficient to control glial guidance. Furthermore, mutations in the transcription factor Sox10/cls uncouple the migration of axons and glia. Finally, genetic ablation of this glial subtype reveals an essential role in nerve fasciculation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping