PUBLICATION

Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds

Authors
Hammond, K.L., Hill, R.E., Whitfield, T.T., and Currie, P.D.
ID
ZDB-PUB-020220-6
Date
2002
Source
Mechanisms of Development   112(1-2): 183-189 (Journal)
Registered Authors
Currie, Peter D., Hammond, Katherine L., Whitfield, Tanya T.
Keywords
eye; ear; otic vesicle; sensory patch; lateral line; sensory ridge; neuromast; forebrain; hypothalamus; diencephalon; midbrain; habenula; dorsal thalamus; hindbrain; rhombomere; trigeminal ganglion; spinal neuron; spinal cord; pronephros; somite
MeSH Terms
  • Animals
  • DNA, Complementary/metabolism
  • Zebrafish Proteins/biosynthesis*
  • Zebrafish Proteins/genetics
  • Nuclear Proteins/biosynthesis*
  • Nuclear Proteins/genetics
  • Eye/embryology
  • Drosophila Proteins*
  • Central Nervous System/embryology*
  • Zebrafish
  • Tissue Distribution
  • Time Factors
  • Extremities/embryology*
  • Gene Library
  • Amino Acid Sequence
  • In Situ Hybridization
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
PubMed
11850192 Full text @ Mech. Dev.
Abstract
Drosophila dachshund (dac) interacts with sine oculis (so), eyes absent (eya) and eyeless (ey) to control compound eye development. We have cloned three zebrafish dac homologues, dachA, dachB and dachC, which are expressed widely, in distinct but overlapping patterns. Expression of all three is found in sensory organs, the central nervous system and pectoral fin buds. dachA is also expressed strongly in the somites and dachC in the neural crest and pronephros. These expression domains overlap extensively with those of zebrafish pax, eya and six family members, the homologues of Drosophila ey, eya and so, respectively. This is consistent with the proposal that Dach, Eya, Six and Pax family members may form networks, similar to that found in the fly eye, in the development of many vertebrate organs.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping