PUBLICATION
Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds
- Authors
- Hammond, K.L., Hill, R.E., Whitfield, T.T., and Currie, P.D.
- ID
- ZDB-PUB-020220-6
- Date
- 2002
- Source
- Mechanisms of Development 112(1-2): 183-189 (Journal)
- Registered Authors
- Currie, Peter D., Hammond, Katherine L., Whitfield, Tanya T.
- Keywords
- eye; ear; otic vesicle; sensory patch; lateral line; sensory ridge; neuromast; forebrain; hypothalamus; diencephalon; midbrain; habenula; dorsal thalamus; hindbrain; rhombomere; trigeminal ganglion; spinal neuron; spinal cord; pronephros; somite
- MeSH Terms
-
- Extremities/embryology*
- Eye/embryology
- Nuclear Proteins/biosynthesis*
- Nuclear Proteins/genetics
- DNA, Complementary/metabolism
- Time Factors
- In Situ Hybridization
- Sequence Homology, Amino Acid
- Gene Library
- Drosophila Proteins*
- Amino Acid Sequence
- Tissue Distribution
- Zebrafish
- Zebrafish Proteins/biosynthesis*
- Zebrafish Proteins/genetics
- Molecular Sequence Data
- Animals
- Central Nervous System/embryology*
- PubMed
- 11850192 Full text @ Mech. Dev.
Citation
Hammond, K.L., Hill, R.E., Whitfield, T.T., and Currie, P.D. (2002) Isolation of three zebrafish dachshund homologues and their expression in sensory organs, the central nervous system and pectoral fin buds. Mechanisms of Development. 112(1-2):183-189.
Abstract
Drosophila dachshund (dac) interacts with sine oculis (so), eyes absent (eya) and eyeless (ey) to control compound eye development. We have cloned three zebrafish dac homologues, dachA, dachB and dachC, which are expressed widely, in distinct but overlapping patterns. Expression of all three is found in sensory organs, the central nervous system and pectoral fin buds. dachA is also expressed strongly in the somites and dachC in the neural crest and pronephros. These expression domains overlap extensively with those of zebrafish pax, eya and six family members, the homologues of Drosophila ey, eya and so, respectively. This is consistent with the proposal that Dach, Eya, Six and Pax family members may form networks, similar to that found in the fly eye, in the development of many vertebrate organs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping