PUBLICATION
astray, a zebrafish roundabout homolog required for retinal axon guidance
- Authors
- Fricke, C., Lee, J.S., Geiger-Rudolph, S., Bonhoeffer, F., and Chien, C.-B.
- ID
- ZDB-PUB-010423-3
- Date
- 2001
- Source
- Science (New York, N.Y.) 292(5516): 507-510 (Journal)
- Registered Authors
- Bonhoeffer, Friedrich, Chien, Chi-Bin, Fricke, Cornelia, Geiger-Rudolph, Silke, Lee, Jeong-Soo
- Keywords
- none
- MeSH Terms
-
- Alleles
- Animals
- Axons/physiology*
- Body Patterning
- Chromosome Mapping
- Crosses, Genetic
- Eye/embryology
- Eye/transplantation
- Female
- Gene Expression Regulation, Developmental
- Genes
- In Situ Hybridization
- Male
- Mutation
- Nerve Tissue Proteins/genetics*
- Nerve Tissue Proteins/physiology
- Phenotype
- Receptors, Immunologic/genetics*
- Receptors, Immunologic/physiology*
- Retina/embryology
- Retina/metabolism
- Retinal Ganglion Cells/metabolism
- Retinal Ganglion Cells/physiology*
- Superior Colliculi/cytology
- Superior Colliculi/embryology*
- Visual Pathways/embryology
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish Proteins
- PubMed
- 11313496 Full text @ Science
Citation
Fricke, C., Lee, J.S., Geiger-Rudolph, S., Bonhoeffer, F., and Chien, C.-B. (2001) astray, a zebrafish roundabout homolog required for retinal axon guidance. Science (New York, N.Y.). 292(5516):507-510.
Abstract
As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection. Eye transplantation experiments show that astray function is required in the eye. We identify astray as zebrafish robo2, a member of the Roundabout family of axon guidance receptors. Retinal ganglion cells express robo2 as they extend axons. Thus, robo2 is required for multiple axon guidance decisions during establishment of the vertebrate visual projection
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping