PUBLICATION
Mitochondrial proton leak and the uncoupling protein 1 homologues
- Authors
- Stuart, J.A., Cadenas, S., Jekabsons, M.B., Roussel, D., and Brand, M.D.
- ID
- ZDB-PUB-010410-1
- Date
- 2001
- Source
- Biochim. Biophys. Acta Bio-Energetics 1504(1): 144-158 (Review)
- Registered Authors
- Keywords
- mitochondrion; proton conductance; basal metabolic rate; respiration; UCP1; UCP2; BMCP1; fatty acid; brown adipose tissue; thermogenesis; zebrafish; carp
- MeSH Terms
-
- Amino Acid Sequence
- Humans
- Protons*
- Ion Channels
- Molecular Sequence Data
- Sequence Homology
- Proteins/metabolism
- Models, Animal
- Membrane Transport Proteins*
- Diffusion
- Carrier Proteins/chemistry
- Carrier Proteins/metabolism*
- Mitochondria/metabolism*
- Animals, Genetically Modified
- Basal Metabolism
- Membrane Proteins/chemistry
- Membrane Proteins/metabolism*
- Animals
- Intracellular Membranes/metabolism
- Mitochondrial Proteins*
- RNA, Messenger/metabolism
- Sequence Alignment
- PubMed
- 11239491 Full text @ Biochim. Biophys. Acta Bio-Energetics
Citation
Stuart, J.A., Cadenas, S., Jekabsons, M.B., Roussel, D., and Brand, M.D. (2001) Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim. Biophys. Acta Bio-Energetics. 1504(1):144-158.
Abstract
Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of proton conductance. The uncoupling protein 1 homologues (e.g. UCP2, UCP3) may play a role in mediating proton leak, but it is unlikely they account for all of the observed proton conductance. Experimental data regarding the functions of these proteins include important ambiguities and contradictions which must be addressed before their function can be confirmed. The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping