PUBLICATION
Expression of zebrafish Hoxa1a in neuronal cells of the midbrain and anterior hindbrain
- Authors
- Shih, L., Tsay, H., Lin, S., and Hwang, S.L.
- ID
- ZDB-PUB-010315-9
- Date
- 2001
- Source
- Mechanisms of Development 101(1-2): 279-281 (Journal)
- Registered Authors
- Hwang, Sheng-Ping L., Tsay, Huey-Jen
- Keywords
- zebrafish; Danio rerio; hoxala mRNA; neuronal cell; midbrain/hindbrain boundary; ventral expression; ihh
- MeSH Terms
-
- Mesencephalon/embryology*
- Homeodomain Proteins/biosynthesis*
- Time Factors
- Neurons/metabolism
- Zebrafish/embryology*
- Sequence Homology, Amino Acid
- Mice
- Transcription Factors/biosynthesis*
- Base Sequence
- In Situ Hybridization
- Amino Acid Sequence
- Rhombencephalon/embryology*
- Animals
- Molecular Sequence Data
- Tissue Distribution
- PubMed
- 11231091 Full text @ Mech. Dev.
Citation
Shih, L., Tsay, H., Lin, S., and Hwang, S.L. (2001) Expression of zebrafish Hoxa1a in neuronal cells of the midbrain and anterior hindbrain. Mechanisms of Development. 101(1-2):279-281.
Abstract
The expression pattern of zebrafish hoxa1a mRNA during embryonic development was studied. Herein, we show that hoxa1a mRNA is expressed in the ventral region of both the midbrain and anterior hindbrain during the developmental period from the pharyngula to the protruding-mouth stages via whole-mount in situ hybridization. Furthermore, double-labeling with anti-zHu antibody confirms that the zebrafish hoxa1a gene is expressed in neuronal cells. The observed temporal and spatial distributions of zebrafish hoxa1a mRNA differ greatly from the expression patterns of zebrafish hoxb1a and hoxb1b paralagous genes. In addition, in embryos injected with mouse ihh mRNA, hoxa1a-expressing cells increase in number with a dorsalized expression pattern in the midbrain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping