PUBLICATION

Evolutionary origins of vertebrate appendicular muscle

Authors

Neyt, C., Jagla, K., Thisse, C., Thisse, B., Haines, L., and Currie, P.D.

ID

ZDB-PUB-001205-1

Date

2000

Source

Nature 408(6808): 82-86 (Journal)

Registered Authors

Currie, Peter D., Haines, Lynn, Neyt, Christine, Thisse, Bernard, Thisse, Christine

Keywords

none

MeSH Terms

Animals
Biological Evolution*
Cell Differentiation
Embryonic Development
Extremities/embryology
Fishes
Morphogenesis
Muscles/embryology*
MyoD Protein/biosynthesis
MyoD Protein/genetics
Zebrafish

PubMed

11081511 Full text @ Nature

Abstract

The evolution of terrestrial tetrapod species heralded a transition in locomotor strategies. While most fish species use the undulating contractions of the axial musculature to generate propulsive force, tetrapods also rely on the appendicular muscles of the limbs to generate movement. Despite the fossil record generating an understanding of the way in which the appendicular skeleton has evolved to provide the scaffold for tetrapod limb musculature, there is, by contrast, almost no information as to how this musculature arose. Here we examine fin muscle formation within two extant classes of fish. We find that in the teleost, zebrafish, fin muscles arise from migratory mesenchymal precursor cells that possess molecular and morphogenetic identity with the limb muscle precursors of tetrapod species. Chondrichthyan dogfish embryos, however, use the primitive mechanism of direct epithelial somitic extensions to derive the muscles of the fin. We conclude that the genetic mechanism controlling formation of tetrapod limb muscles evolved before the Sarcopterygian radiation.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Neyt et al., 2000 ZDB-PUB-001205-1 PMID:11081511

Evolutionary origins of vertebrate appendicular muscle

Neyt et al., 2000

ZDB-PUB-001205-1
PMID:11081511