PUBLICATION
Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace
- Authors
- Adamska, M., Leger, S., Brand, M., Hadrys, T., Braun, T., and Bober, E.
- ID
- ZDB-PUB-001019-4
- Date
- 2000
- Source
- Mechanisms of Development 97(1-2): 161-165 (Journal)
- Registered Authors
- Brand, Michael
- Keywords
- homeobox; Nkx genes; FGF8; inner ear; lateral line; zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Brain/embryology
- Brain/metabolism
- DNA, Complementary
- Down-Regulation*
- Ear, Inner/embryology
- Ear, Inner/metabolism*
- Fibroblast Growth Factor 8
- Fibroblast Growth Factors/genetics*
- Gene Expression Regulation, Developmental*
- Homeodomain Proteins/genetics*
- Humans
- Mechanoreceptors/embryology
- Mechanoreceptors/metabolism
- Mice
- Molecular Sequence Data
- Nerve Tissue Proteins/genetics*
- Rats
- Sequence Homology, Amino Acid
- Signal Transduction
- Zebrafish
- PubMed
- 11025218 Full text @ Mech. Dev.
Citation
Adamska, M., Leger, S., Brand, M., Hadrys, T., Braun, T., and Bober, E. (2000) Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace. Mechanisms of Development. 97(1-2):161-165.
Abstract
An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo-acoustic ganglion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping