PUBLICATION
An inherited functional circadian clock in zebrafish embryos
- Authors
- Delaunay, F., Thisse, C., Marchand, O., Laudet, V., and Thisse, B.
- ID
- ZDB-PUB-000726-8
- Date
- 2000
- Source
- Science (New York, N.Y.) 289(5477): 297-300 (Journal)
- Registered Authors
- Delaunay, Franck, Laudet, Vincent, Marchand, Oriane, Thisse, Bernard, Thisse, Christine
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Circadian Rhythm*/genetics
- DNA-Binding Proteins*
- Embryo, Nonmammalian/metabolism
- Embryonic Development
- Female
- Gene Expression Regulation, Developmental
- Light
- Molecular Sequence Data
- Nuclear Proteins/genetics*
- Nuclear Proteins/physiology
- Period Circadian Proteins
- Proteins/genetics
- Receptors, Cytoplasmic and Nuclear*
- Transcription Factors
- Zebrafish/embryology
- Zebrafish/physiology*
- Zebrafish Proteins
- PubMed
- 10894777 Full text @ Science
Citation
Delaunay, F., Thisse, C., Marchand, O., Laudet, V., and Thisse, B. (2000) An inherited functional circadian clock in zebrafish embryos. Science (New York, N.Y.). 289(5477):297-300.
Abstract
Circadian clocks are time-keeping systems found in most organisms. In zebrafish, expression of the clock gene Period3 (Per3) oscillates throughout embryogenesis in the central nervous system and the retina. Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression. Per3 messenger RNA accumulates rhythmically in oocytes and persists in embryos. Our results establish that the circadian clock functions during early embryogenesis in zebrafish. Inheritance of maternal clock gene products suggests a mechanism of phase inheritance through ovogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping