PUBLICATION
Developmental regulation of Tbx5 in zebrafish embryogenesis
- Authors
- Begemann, G. and Ingham, P.W.
- ID
- ZDB-PUB-000118-15
- Date
- 2000
- Source
- Mechanisms of Development 90(2): 299-304 (Journal)
- Registered Authors
- Begemann, Gerrit, Ingham, Philip
- Keywords
- T-box; Tbx5; Holt-Oram syndrome; lateral plate mesoderm; heart; pectoral fin; apical fold; limb development; retina; zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA, Complementary
- Gene Expression Regulation, Developmental*
- Humans
- Mice
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- T-Box Domain Proteins/genetics*
- Tissue Distribution
- Zebrafish
- PubMed
- 10640716 Full text @ Mech. Dev.
Citation
Begemann, G. and Ingham, P.W. (2000) Developmental regulation of Tbx5 in zebrafish embryogenesis. Mechanisms of Development. 90(2):299-304.
Abstract
T-box (tbx) genes constitute a large family of transcriptional regulators involved in developmental patterning processes. In tetrapods, tbx5 has been implicated in specifying forelimb type identity. Here, we report the cloning of the zebrafish tbx5.1 gene and characterise its expression during zebrafish embryogenesis and early larval development of wild type and mutant embryos that affect pectoral fin patterning. tbx5.1 is expressed during development of the heart, the pectoral fins and the eye. Notably, its expression in the lateral plate mesoderm defines a single and continuous region of heart and pectoral fin precursor cells, and constitutes the earliest specific marker for pectoral fin development in the zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping