PUBLICATION
Cell mosaic patterns in the native and regenerated inner retina of zebrafish: implications for retinal assembly
- Authors
- Cameron, D.A. and Carney, L.H.
- ID
- ZDB-PUB-000118-12
- Date
- 2000
- Source
- The Journal of comparative neurology 416(3): 356-367 (Journal)
- Registered Authors
- Cameron, David A.
- Keywords
- Danio rerio; regeneration; pattern formation; amacrine cells; bipolar cells; retinal ganglion cells
- MeSH Terms
-
- Animals
- Cell Size
- Mosaicism/physiopathology*
- Nerve Regeneration/physiology*
- Neurons/chemistry
- Neurons/cytology*
- Retina/chemistry
- Retina/cytology*
- Zebrafish/anatomy & histology*
- PubMed
- 10602094 Full text @ J. Comp. Neurol.
Citation
Cameron, D.A. and Carney, L.H. (2000) Cell mosaic patterns in the native and regenerated inner retina of zebrafish: implications for retinal assembly. The Journal of comparative neurology. 416(3):356-367.
Abstract
In part because of its laminar organization and morphologically distinct cell populations, the vertebrate retina has often been used as a system for investigating the assembly of neural structures. The retinas of adult teleost fish, because they grow throughout life and can regenerate following an injury, provide an especially attractive model system for such investigations. In an effort to provide a quantitative foundation for testing hypotheses regarding the mechanisms of pattern formation during growth and regeneration of the vertebrate retina, nearest neighbor and auto-correlation analyses were used to examine the mosaic patterns of eight inner retinal cell groups in the native and regenerated retina of adult zebrafish. In both native and regenerated retina, the mosaic patterns of most inner retinal cells are non-random. However, regenerated mosaics tend toward significantly lower nearest neighbor distances, less orderly patterns, and more variable radial locations than their native retina counterparts. The individual cell groups in both native and regenerated inner retina are likely to be spatially distributed independently. The results support the hypotheses that, in the adult zebrafish: 1) distinct inner retinal cell groups of native retina are also present in regenerated retina; 2) the assembly of inner retinal cell mosaics is controlled by non-random spatial organizing mechanisms during development, growth, and regeneration; and 3) the spatial organization of cell mosaics is disrupted during regeneration. The results suggest that retinal regeneration may represent a spatially disrupted recapitulation of retinal developmental mechanisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping