Person
Gong, Hong-Yi
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Biography and Research Interest
2008~ Assistant Professor, Division of Life Science, Department of Aquaculture, National Taiwan Ocean University, Taiwan
2004~2008 Post-doctoral Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2004 Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan
My current research activities focus on the following areas:
(1) Functional genomics approach to study regulatory mechanism of growth factors and transcription factors involved in the growth of teleosts; (2) Establishment of functional genes as molecular markers of breeding to improve broodstock of the grouper and tilapia for growth promotion and disease-resistance; (3) Development of muscle-specific promoter/enhancer applied in transgenic fish to study functional genes in fish muscle growth and regeneration and to use fish muscle as bioreactor to produce interested proteins; (4) Zebrafish as an animal model to investigate molecular mechanisms of liver development and human liver diseases from steatosis to liver cancers.
2004~2008 Post-doctoral Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2004 Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan
My current research activities focus on the following areas:
(1) Functional genomics approach to study regulatory mechanism of growth factors and transcription factors involved in the growth of teleosts; (2) Establishment of functional genes as molecular markers of breeding to improve broodstock of the grouper and tilapia for growth promotion and disease-resistance; (3) Development of muscle-specific promoter/enhancer applied in transgenic fish to study functional genes in fish muscle growth and regeneration and to use fish muscle as bioreactor to produce interested proteins; (4) Zebrafish as an animal model to investigate molecular mechanisms of liver development and human liver diseases from steatosis to liver cancers.
Non-Zebrafish Publications
Hu, S. Y., Chen, M. H. C., Lin, Y. C., Lin, G. H., Gong, H. Y., Wu, J. L. (2008). Cloning and functional analysis of the proximal promoter region of the three GnRH genes from silver sea bream (Sparus sarba). Comparative Biochemistry and Physiology B Biochem. Mol. Biol. 151: 373-380. Lin, C. J. F., Gong, H. Y., Tseng, H. C., Wang, W. L., Wu, J. L. (2008). miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem. Bioph. Res. Co. 375: 315-320.
Huang, W. T., Yu, H. C., Hsu, C. C., Liao, C. F., Gong, H. Y., Lin, C. J. F., Wu, J. L., and Weng, C. F. (2007). Steroid hormones (17beta-estradiol and hydrocortisone) upregulate hepatocyte nuclear factor (HNF)-3beta and insulin-like growth factor I and II expression in the gonads of tilapia (Oreochromis mossambicus) in vitro. Theriogenology 68: 988-1002.
Chen, M. H. C., Li, Y. H., Chang, Y., Hu, S. Y., Gong, H. Y. , Lin, G. H., Chen, T. T. and Wu, J. L. (2007). Co-induction of hepatic IGF-1 and progranulin mRNA by growth hormone in tilapia (Oreochromis mossambicus). General Comparative Endocrinology 150: 212-218.
Hu, S. Y., Huang, J. H., Huang, W. T., Yeh, Y. H., Chen, M. H. C., Gong, H. Y. , Chiou T. T., Yang, T. H., Chen, T. T., Lu, J. K. and Wu, J. L. (2006). Structure and function of antimicrobial peptide penaeidin-5 from the black tiger shrimp Penaeus monodon. Aquaculture 260: 61-68.
Gong, H. Y., Wu, J. L., Huang, W. T., Lin, C. J. F., and Weng, C. F. (2004). Response to acute changes in salinity of two different muscle type creatine kinase isoforms, from euryhaline teleost (Oreochromis mossambicus) gills. Bioch. Biophy. Acta 1675: 184-191.
Lin, L.Y., Chiang, C.C., Gong, H.Y., Cheng, C.Y., Hwang, P.P. and Weng, C.F. (2003). Cellular Distributions of Creatine Kinase in Branchia of Euryhaline Tilapia (Oreochromis mossambicus). Am J Physiol Cell Physiol 284: C233¡VC241.
Hong, J.R., Gong, H.Y. and Wu, J.L. (2002). IPNV VP5, a novel anti-apoptosis of Bcl-2 family, regulates Mcl-1 and viral protein expression. Virology 295: 217-229.
Weng, C.F., Chiang, C.C., Gong, H.Y., Chen, M.H.C., Lin, C.J.F., Hwang, P.P. and Wu, J.L. (2002). Acute branchial response to salinity changes in euryhaline teleost (Oreochromis mossambicus). Physiol. and Biochem. Zool. 75: 29-36.
Weng, C.F., Chiang, C.C., Gong, H.Y., Chen, M.H.C., Huang, W.T., Cheng, C.Y. and Wu, J.L. (2002).Bioenergetics of adaptation to a salinity transition in euryhaline teleost (Oreochromis mossambicus) brain. Exp. Biol. Med. 227: 45-50.
Huang, W.T., Gong, H.Y., Lin, C.J., Weng, C.F., Chen, M.H., and Wu, J.L. (2001) Hepatocyte nuclear factors-1alpha, -1beta, and -3beta expressed in the gonad of tilapia (Oreochromis mossambicus). Biochem. Biophys. Res. Commun.. 288(4):833-840
Weng, C.F., Gong, H.Y., Wu, J.L., Hew, C.L. and Hwang, P.P. (2000). Antagonizing effects of type I antifreeze protein on Ca++ uptake in fish TO2 cells. Zool. Stud. 39:144-150.
Chen, M. H.C., Lin, G.H., Gong, H.Y., Lee, C.Y., Chang, C.Y., Chen, T.T. and Wu, J.L. (1998). Cloning and characterization of insulin-like growth factor I cDNA from black seabream (Acanthopagrus schlegeli). Zool. Stud. 37: 213-221.