Person
Challa, Anil Kumar
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Biography and Research Interest
I am broadly interested in understanding the mechanisms underlying cell movements during vertebrate embryogenesis. I have been interested in the Roundabout (Robo) family of receptor proteins and their role in a variety of developmental events. The Robo family has multiple orthologs/paralogs owing to duplication events during evolution, and to multiple isoforms possibly owing to complex molecular genetic regulation. The zebrafish provides a tractable system to study genetics and cell biology of the Robo family of proteins.
As part of a collaborative effort with Dr.Kiranam Chatti at the Institute of Life Sciences (Hyderabad, India), I got interested in protein tyrosine kinases in the zebrafish genome. One of the goals of this effort is to identify and characterize, all the tyrosine kinase genes important in specific developmental events.
I am also interested in exploiting zebrafish as a model organism in high school and undergraduate science education.
As part of a collaborative effort with Dr.Kiranam Chatti at the Institute of Life Sciences (Hyderabad, India), I got interested in protein tyrosine kinases in the zebrafish genome. One of the goals of this effort is to identify and characterize, all the tyrosine kinase genes important in specific developmental events.
I am also interested in exploiting zebrafish as a model organism in high school and undergraduate science education.
Non-Zebrafish Publications
Google Scholar
1: Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD, Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF. Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. PLoS Genet. 2016 Jul 29;12(7):e1006220. doi:10.1371/journal.pgen.1006220. eCollection 2016 Jul. PubMed PMID: 27472056.
2: Challa, Anil K., Evan R. Boitet, Ashley N. Turner, Larry W. Johnson, Daniel Kennedy, Ethan R. Downs, Katherine M. Hymel, Alecia K. Gross, and Robert A. Kesterson. (2016) "Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes." PLoS ONE 11, no. 5: e0155812.
3: Chen HY, Challa AK, Varki A. (2006) 9-O-acetylation of exogenously added ganglioside GD3. The GD3 molecule induces its own O-acetylation machinery. J Biol Chem. 281(12):7825-33.