Person

Holtzman, Nathalia Glickman

Person ID
ZDB-PERS-970217-7
Email
nathalia.holtzman@qc.cuny.edu
URL
http://qcpages.qc.edu/Biology/Holtzman/Holtzman.html
Affiliation
Holtzman Lab
Address
Queens College SB D328 65-30 Kissena Blv Flushing, NY 11367 USA
Country
United States
Phone
718-997-3678
Fax
718-997-3445
ORCID ID
Biography and Research Interest
During heart formation, cardiac precursors start out as bilateral sheets of cells that move toward the midline, where they converge, surround the central endocardium, and rearrange to create the heart tube. Though the tissue level shape changes that occur during heart tube formation are beginning to be understood, little is known about the cell behaviors or the molecular regulation of this process. Tracking the movement of individual GFP-expressing cardiomyocytes in wild-type zebrafish embryos and in zebrafish mutants with heart tube defects suggests that highly regulated, coordinated cell movements are required to form the heart.

We are currently examining the role of the endoderm, endocardium and yolk in directing the movement of the myocardium.
Publications
Non-Zebrafish Publications
Larsen E., Lee, T. and Glickman, N. (1996). Antenna to leg transformation: dynamics of developmental competence. Dev Genet. 19(4):333-9.