Person
Takahashi, Tokiharu
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Biography and Research Interest
Evolutionary Developmental Biology
I was originally a practising clinician as well as a research scientist in haematology and oncology at the University of Tokyo Hospital, Japan. During my research, I became more interested in the diversity of animal species as a result of modification of developmental process. Consequently, I joined the laboratory of Professor Peter Holland in 2001, where I focused on evolutionary developmental biology. Here in Manchester, my long-term scientific goal is to rejuvenate a comparative zoological approach to life sciences by bringing my two areas of expertise together.
Education
1984-1990 MD: Faculty of Medicine, University of Tokyo
1990-1992 Resident: University of Tokyo Hospital and Tokyo Kosei Nenkin Hospital
1992-1996 PhD: Graduate School of Medicine, University of Tokyo
Appointments
1996-1999 Clinical Staff: Department of Haematology and Oncology, and Department of Transfusion, University of Tokyo Hospital
1999-1999 Postdoctoral Research Scientist (JSPS): Department of Haematology and Oncology, University of Tokyo
1999-2001 Junior Assistant Professor: Department of Haematology and Oncology, University of Tokyo
2001-2002 JSPS/Royal Society (London) Exchange Visitor: School of Animal and Microbial Sciences, University of Reading
2003-2006 Senior Research Fellow: Department of Zoology, University of Oxford
2007-pres. Lecturer in Anatomy: Faculty of Life Sciences, University of Manchester
I was originally a practising clinician as well as a research scientist in haematology and oncology at the University of Tokyo Hospital, Japan. During my research, I became more interested in the diversity of animal species as a result of modification of developmental process. Consequently, I joined the laboratory of Professor Peter Holland in 2001, where I focused on evolutionary developmental biology. Here in Manchester, my long-term scientific goal is to rejuvenate a comparative zoological approach to life sciences by bringing my two areas of expertise together.
Education
1984-1990 MD: Faculty of Medicine, University of Tokyo
1990-1992 Resident: University of Tokyo Hospital and Tokyo Kosei Nenkin Hospital
1992-1996 PhD: Graduate School of Medicine, University of Tokyo
Appointments
1996-1999 Clinical Staff: Department of Haematology and Oncology, and Department of Transfusion, University of Tokyo Hospital
1999-1999 Postdoctoral Research Scientist (JSPS): Department of Haematology and Oncology, University of Tokyo
1999-2001 Junior Assistant Professor: Department of Haematology and Oncology, University of Tokyo
2001-2002 JSPS/Royal Society (London) Exchange Visitor: School of Animal and Microbial Sciences, University of Reading
2003-2006 Senior Research Fellow: Department of Zoology, University of Oxford
2007-pres. Lecturer in Anatomy: Faculty of Life Sciences, University of Manchester
Non-Zebrafish Publications
2013
Dee, C., Szymoniuk, C., Mills, P. & Takahashi, T (2013). Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia. Hum Mol Genet, 22(2), 239-51. eScholarID:213608 | PMID:23059813 | DOI:10.1093/hmg/dds423
2011
McGonnell, I., Graham, A., Richardson, J., Fish, J., Depew, M., Dee, C., Holland, P. & Takahashi, T (2011). Evolution of the Alx homeobox gene family: parallel retention and independent loss of the vertebrate Alx3 gene. Evol Dev, 13(4), 343-351. eScholarID:127069 | PMID:21740507 | DOI:10.1111/j.1525-142X.2011.00489.x
2010
Hui, J., Hayward, A., Bendena, W., Takahashi, T. & Tobe, S (2010). Evolution and functional divergence of enzymes involved in sesquiterpenoid hormone biosynthesis in crustaceans and insects. Peptides, 31(3), 451-5. eScholarID:77415 | PMID:19836428 | DOI:10.1016/j.peptides.2009.10.003
Hayward, A., Takahashi, T., Bendena, W., Tobe, S. & Hui, J (2010). Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans. FEBS Lett, eScholarID:77413 | PMID:20188099 | DOI:10.1016/j.febslet.2010.02.056
2009
Takahashi, T., McDougall, C., Troscianko, J., Chen, W., Jayaraman-Nagarajan, A., Shimeld, S. & Ferrier, D (2009). An EST screen from the annelid Pomatoceros lamarckii reveals patterns of gene loss and gain in animals. BMC Evol Biol, 9, 240. eScholarID:75487 | PMID:19781084 | DOI:10.1186/1471-2148-9-240
2008
McDougall C, Hui JH, Monteiro A, Takahashi T, Ferrier DE. (2008). Annelids in evolutionary developmental biology and comparative genomics. Parasite (Paris, France), 15(3), 321-8. eScholarID:1c7895 | PMID:18814702
2005
Takahashi T. (2005). The evolutionary origins of vertebrate midbrain and MHB: insights from mouse, amphioxus and ascidian Dmbx homeobox genes. Brain research bulletin, 66(4-6), eScholarID:1c6205 | PMID:16144640 | DOI:10.1016/j.brainresbull.2005.03.013
Holland PW, Takahashi T. (2005). The evolution of homeobox genes: Implications for the study of brain development. Brain research bulletin, 66(4-6), 484-90. eScholarID:1c6202 | PMID:16144637 | DOI:10.1016/j.brainresbull.2005.06.003
2004
Takahashi T, Holland PW. (2004). Amphioxus and ascidian Dmbx homeobox genes give clues to the vertebrate origins of midbrain development. Development (Cambridge, England), 131(14), 3285-94. eScholarID:1c6203 | PMID:15201221 | DOI:10.1242/dev.01201
2003
Kumano K, Chiba S, Kunisato A, Sata M, Saito T, Nakagami-Yamaguchi E, Yamaguchi T, Masuda S, Shimizu K, Takahashi T, Ogawa S, Hamada Y, Hirai H. (2003). Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity, 18(5), 699-711. eScholarID:1c6206 | PMID:12753746 | DOI:10.1016/S1074-7613(03)00117-1
2002
Takahashi T, Holland PW, Cohn MJ, Shimizu K, Kurokawa M, Hirai H. (2002). An orphan PRD class homeobox gene expressed in mouse brain and limb development. Development genes and evolution, 212(6), eScholarID:1c6204 | PMID:12111214 | DOI:10.1007/s00427-002-0244-1
Yamaguchi E, Chiba S, Kumano K, Kunisato A, Takahashi T, Takahashi T, Hirai H. (2002). Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice. Immunology letters, 81(1), 59-64. eScholarID:1c6207 | PMID:11841846 | DOI:10.1016/S0165-2478(01)00326-1
Tanaka Y, Takahashi T, Nieda M, Masuda S, Kashiwase K, Takahashi T, Ogawa S, Chiba S, Juji T, Hirai H. (2002). Generation of Fas-independent CD4+ cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide. Leukemia research, 26(3), 317-21. eScholarID:1c6209 | PMID:11792422 | DOI:10.1016/S0145-2126(01)00119-9
Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H. (2002). Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. The EMBO journal, 21(3), 294-302. eScholarID:1c6208 | PMID:11823422 | DOI:10.1093/emboj/21.3.294
2001
Kumano K, Chiba S, Shimizu K, Yamagata T, Hosoya N, Saito T, Takahashi T, Hamada Y, Hirai H. (2001). Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. Blood, 98(12), 3283-9. eScholarID:1c6210 | PMID:11719365 | DOI:10.1182/blood.V98.12.3283
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H. (2001). Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. The Journal of biological chemistry, 276(28), 25753-8. eScholarID:1c6211 | PMID:11346656 | DOI:10.1074/jbc.M103473200
2000
Kurokawa M, Mitani K, Yamagata T, Takahashi T, Izutsu K, Ogawa S, Moriguchi T, Nishida E, Yazaki Y, Hirai H. (2000). The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death. The EMBO journal, 19(12), 2958-68. eScholarID:1c6212 | PMID:10856240 | DOI:10.1093/emboj/19.12.2958
Takahashi T, Hirano N, Takahashi T, Chiba S, Yazaki Y, Hirai H. (2000). Immunogene therapy against mouse leukemia using B7 molecules. Cancer gene therapy, 7(1), 144-50. eScholarID:1c6213 | PMID:10678367 | DOI:10.1038/sj.cgt.7700099
Miyazaki T, Takayanagi H, Isshiki M, Takahashi T, Okada M, Fukui Y, Oda H, Nakamura K, Hirai H, Kurokawa T, Tanaka S. (2000). In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(1), 41-51. eScholarID:1c6214 | PMID:10646113
1999
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H. (1999). Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. The Journal of biological chemistry, 274(46), 32961-9. eScholarID:1c6215 | PMID:10551863 | DOI:10.1074/jbc.274.46.32961
Takayanagi H, Juji T, Miyazaki T, Iizuka H, Takahashi T, Isshiki M, Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, Nakamura K, Tanaka S. (1999). Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. The Journal of clinical investigation, 104(2), 137-46. eScholarID:1c6227 | PMID:10411542
1998
Tanaka S, Takahashi T, Takayanagi H, Miyazaki T, Oda H, Nakamura K, Hirai H, Kurokawa T. (1998). Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 13(11), 1714-20. eScholarID:1c6216 | PMID:9797480
Kurokawa M, Mitani K, Irie K, Matsuyama T, Takahashi T, Chiba S, Yazaki Y, Matsumoto K, Hirai H. (1998). The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature, 394(6688), 92-6. eScholarID:1c6218 | PMID:9665135
Takahashi T, Yamada K, Tanaka T, Kumano K, Kurokawa M, Hirano N, Honda H, Chiba S, Tsuji K, Yazaki Y, Nakahata T, Hirai H. (1998). A potential molecular approach to ex vivo hematopoietic expansion with recombinant epidermal growth factor receptor-expressing adenovirus vector. Blood, 91(12), 4509-15. eScholarID:1c6219 | PMID:9616146
Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, Wada M, Honjo M, Takahashi M, Takahashi T, Hirai H, Tsushima T, Akanuma Y, Fujita T, Komuro I, Yazaki Y, Kadowaki T. (1998). Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression. Endocrine journal, 45 Suppl, S27-31. eScholarID:1c6217 | PMID:9790226
1997
Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, Wada M, Honjo M, Takahashi M, Takahashi T, Hirai H, Tushima T, Akanuma Y, Fujita T, Komuro I, Yazaki Y, Kadowaki T. (1997). Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature, 390(6655), 91-6. eScholarID:1c6220 | PMID:9363897
Hirano N, Takahashi T, Takahashi T, Azuma M, Okumura K, Yazaki Y, Yagita H, Hirai H. (1997). Protective and therapeutic immunity against leukemia induced by irradiated B7-1 (CD80)-transduced leukemic cells. Human gene therapy, 8(11), 1375-84. eScholarID:1c6221 | PMID:9295132
Chiba S, Takahashi T, Takeshita K, Minowada J, Yazaki Y, Ruddle FH, Hirai H. (1997). Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. Blood, 90(1), 97-104. eScholarID:1c6222 | PMID:9207443
Hirano N, Takahashi T, Takahashi T, Azuma M, Yazaki Y, Yagita H, Hirai H. (1997). Protective and therapeutic immunity against leukemia induced by irradiated B7-1 (CD80)-transduced leukemic cells. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 11 Suppl 3, 577-81. eScholarID:1c6223 | PMID:9209459
Hirai H, Ogawa S, Hangaishi A, Takahashi T, Kurokawa M, Mitani K, Ueda R, Yazaki Y. (1997). Recent progress in molecular mechanisms of leukemogenesis: the cyclin-dependent kinase 4-inhibitor gene in human leukemias. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 11 Suppl 3, 358-60. eScholarID:1c6224 | PMID:9209389
1996
Hirano N, Takahashi T, Takahashi T, Ohtake S, Hirashima K, Emi N, Saito K, Hirano M, Shinohara K, Takeuchi M, Taketazu F, Tsunoda S, Ogura M, Omine M, Saito T, Yazaki Y, Ueda R, Hirai H. (1996). Expression of costimulatory molecules in human leukemias. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 10(7), 1168-76. eScholarID:1c6225 | PMID:8683998
1995
Takahashi T, Chiba S, Hirano N, Yazaki Y, Hirai H. (1995). Characterization of three erythropoietin (Epo)-binding proteins in various human Epo-responsive cell lines and in cells transfected with human Epo-receptor cDNA. Blood, 85(1), 106-14. eScholarID:1c6226 | PMID:7803787
1994
Ogawa S, Hirano N, Sato N, Takahashi T, Hangaishi A, Tanaka K, Kurokawa M, Tanaka T, Mitani K, Yazaki Y. (1994). Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood, 84(8), 2431-5. eScholarID:1c6228 | PMID:7919362