Person
Chatti, Kiranam
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Biography and Research Interest
2013 onwards
Principal Research Scientist and Zebrafish Facility Head, Center for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, India.
2008 onwards
Senior Research Scientist at the Institute of Life Sciences, Dept. of Biology, University of Hyderabad Campus, India.
2005 - 2008
Post-Doctoral Research Associate in the State University of New York at Stony Brook, Dept. of Physiology & Biophysics, New York, USA.
1998 - 2004
Ph.D. in Pharmacology & Toxicology at the University of Mississippi Medical
Center, Jackson, Mississippi, USA.
1997 - 1998
Junior Research Fellow at the Centre for Cellular and Molecular Biology,
Hyderabad.
1995 - 1997
M.Sc. in Biotechnology at Madurai Kamaraj University, Madurai.
1992 - 1995
B.Sc. in Genetics, Botany and Chemistry at Nizam College, Osmania
University, Hyderabad, India.
Research Interests
Protein tyrosine kinases (PTKs) are cellular enzymes which catalyze phosphotransfer from ATP to tyrosine residues in proteins. The human genome encodes 90 tyrosine kinases, the majority of which are directly associated (by overexpression or mutation) with defects in cell proliferation and/or differentiation, resulting in cancer.
A current research effort in my laboratory is to understand tyrosine kinase biology in zebrafish. We have recently published the complete zebrafish tyrosine kinome highlighting their phylogenetic relationships and unique sequence features, using profile hidden markov models. We are studying the expression and role of zebrafish homologs of BRK. Understanding tyrosine kinase dysregulation and cancer in zebrafish is a likely outcome of this work.
A connected research area in my lab is based on the hypothesized regulation of tyrosine kinases by non-catalytic domain interactions with their splice-variants. We are testing this hypothesis by studying the regulation of BRK (breast tumour kinase) signalling by one of its splice-variants, and its effect on cell proliferation. The relevance of such a mechanism in cancer initiation and progression will be studied using human tissue samples.
Principal Research Scientist and Zebrafish Facility Head, Center for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, India.
2008 onwards
Senior Research Scientist at the Institute of Life Sciences, Dept. of Biology, University of Hyderabad Campus, India.
2005 - 2008
Post-Doctoral Research Associate in the State University of New York at Stony Brook, Dept. of Physiology & Biophysics, New York, USA.
1998 - 2004
Ph.D. in Pharmacology & Toxicology at the University of Mississippi Medical
Center, Jackson, Mississippi, USA.
1997 - 1998
Junior Research Fellow at the Centre for Cellular and Molecular Biology,
Hyderabad.
1995 - 1997
M.Sc. in Biotechnology at Madurai Kamaraj University, Madurai.
1992 - 1995
B.Sc. in Genetics, Botany and Chemistry at Nizam College, Osmania
University, Hyderabad, India.
Research Interests
Protein tyrosine kinases (PTKs) are cellular enzymes which catalyze phosphotransfer from ATP to tyrosine residues in proteins. The human genome encodes 90 tyrosine kinases, the majority of which are directly associated (by overexpression or mutation) with defects in cell proliferation and/or differentiation, resulting in cancer.
A current research effort in my laboratory is to understand tyrosine kinase biology in zebrafish. We have recently published the complete zebrafish tyrosine kinome highlighting their phylogenetic relationships and unique sequence features, using profile hidden markov models. We are studying the expression and role of zebrafish homologs of BRK. Understanding tyrosine kinase dysregulation and cancer in zebrafish is a likely outcome of this work.
A connected research area in my lab is based on the hypothesized regulation of tyrosine kinases by non-catalytic domain interactions with their splice-variants. We are testing this hypothesis by studying the regulation of BRK (breast tumour kinase) signalling by one of its splice-variants, and its effect on cell proliferation. The relevance of such a mechanism in cancer initiation and progression will be studied using human tissue samples.
Non-Zebrafish Publications
1. Kumar KS, Rambabu D, Sandra S, Kapavarapu R, Krishna GR, Basaveswara Rao MV, Chatti K, Reddy CM, Misra P, Pal M (2012). AlCl3 induced (hetero)arylation of 2,3-dichloroquinoxaline: a one-pot synthesis of mono/disubstituted quinoxalines as potential antitubercular agents.Bioorg Med Chem. 20(5):1711-22.
2. Xiang B*, Chatti K*, Qiu H, Miller WT, and Muthuswamy SK (2008). BRK is coamplified with ErbB2 to promote proliferation in breast cancer. Proc. Natl. Acad. Sci. USA 105:12463-12468. *Equal Contribution
3. Mamoon NM, Smith JK, Chatti K, Lee S, Kundrapu K, and Duhe RJ (2007). Multiple Cysteine residues are critical to Janus Kinase 2-mediated catalysis. Biochemistry 46: 14810-14818.
4. Chatti K, Farrar WL and Duhe RJ (2004). Tyrosine phosphorylation of the Janus Kinase 2 activation loop is essential for a high activity catalytic state, but dispensible for a basal catalytic state. Biochemistry 43: 4272-4283.