Biography and Research Interest

Publications

Non-Zebrafish Publications

1. Choi E., Choi H., Choi, J-Y., Kim J., and Lee H. (2009). BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing in mitosis. EMBO J. 28: 2077-2089. Epub ahead of print April 30th 2009.


2. Lee Y-K, Park N-H, and Lee H. ALT-associated promyeolycytic leukaaemia body (APB) as a biological marker in uterine sarcoma. (2010). Submitted


3. Lee Y., Choi E., Park P-G., Kim M. A., Park N-H, and Lee H. (2009) BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers. Brit. J. Cancer. 101: 504-510.


4. Choi E., Min J., Choi J-Y., Park P., Kim J., Yun Y., and Lee H. (2010). BRCA2 controls the spindle assembly checkpoint by regulating the acetylation and proteolysis of BubR1. In revision


5. Hwang G., Kim J., Jeong, J-H., Choi, E., Venkitaraman, A., and Lee H. (2009). Involvement of BRCA2 in telomere end protection and suppression of Alternative lengthening of telomeres (ALT). in preparation


6. Nam S., Min K., Hwang H., Lee HO., Lee JH., Yoon, J., Lee H., Park S., Lee J. (2009). Control of Rapsyn stability by the CUL-3-containing E3 ligase complex. (2009). J. Biol. Chem. 284(12):8195-206. Epub ahead of print 2009. Jan. 20.


7. Ko E., Lee J., and Lee H. (co-corresponding) (2008). Essential Role of brc-2 in Chromosome Integrity of Germ Cells in C. elegans. Mol. Cells 26:590-594.


8. Lee, H.N., Kim K.H., Swamy K.M.K., Park M.S. Kim J., Lee H., Lee K-H., Park S., Yoon, J. (2007) New acridine derivatives bearing immobilized azacrown or azathiacrown ligand as fluorescent chemosensors for Hg2+ and Cd2+. Tetrahedron Letters 49: 1261-1265


9. Choi E. and Lee H. (2008). Chromosome damage induces BubR1 activation and prometaphase arrest. FEBS Letters 582:1700-1706


10. Park, P-G. and Lee H. Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus. Exp. Mol. Med. 40: 339-344.


11. Min J., Park P-G., Kho E., Choi E., and Lee H. (2007). Identification of Rad51 regulation by using C. elegans BRCA2 and Bimolcular fluorescence complementation analysis. Biochem Biophys Res Commun. 362 (4): 958-964. Epub 2007. 8. 27.


12. Lee HO., Cho M., Lee J-H., Kim H-S., Yun Y., Lee H. (2007). SuPr-1-mediated desumoylation regulates the repressor activity of ?Np63?. FEBS Letters. 581 (29): 5640-5644


13. Lee HO., Lee J-H., Kim T-Y., and Lee H. (2007). Regulation of ?Np63? by TNF-alpha in Epithelial Homeostasis. FEBS J. 274 (24): 6411-6522. Epub ahead 2007. Nov. 20.


14. Park D., Park I., Lee D. W., Choi Y. B., Lee H., and Yun Y. (2007) The adaptor protein Lad associates with the G protein ? subunit and mediates chemokine-dependent T cell migration. Blood 109 (12): 5122-5128. Epub 2007 Feb 27.


15. Ahn E., Lee H., and Yun Y. (2006). LIME acts as a transmembrane adapter mediating BCR-dependent B cell activation. Blood. 107 (4): 1521-1527. Epub 2005. Oct. 25.


16. Shin H-J., Baek K-H., Jeon A-H, Park M-T., Lee S-J, Kang C-M., Lee H., Yoo S-H., Chung D-H., Sung Y-C., McKeon F., and Lee C-W. (2003). Dual Roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 4: 483-497.


17. Lee H.O, Lee J-H., Choi E., Seol J., Yun Y., and Lee H. (2006). A dominant negative form of p63 inhibits apoptosis in a p53-independent manner.
Biochem Biophys Res Commun. 344(1):166-72. Epub 2006 Apr 17.


18. Lee H. Impaired phosphorylation and mis-localization of Bub1 and BubR1 is responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas Exp. Mol. Med. 35: 448-453.


19. Hur E. M., Son M. Y., Lee O. H, Choi Y. B., Park C. W., Lee H., and Yun Y. (Co-corresponding author) (2003). Lime, a novel transmembrane adaptor protein associates with p56lck and mediates T cell activation. J. Exp. Med. 198(10):1463-1473.


20. Lee C., Chang J. H., Lee H., and Cho Y. (2002) Structural Basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes & Dev. 16: 3199-3212.


21. Lee H., Trainer A. H., Friedman L. S., Thistlethwaite F. C., Evans M. J., Ponder B. A., and Venkitaraman A. R. (1999). Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Molecular Cell 4, 1-10.


22. Patel K. J., Yu V. P., Lee H., Corcoran A., Thistlethwaite F. C., Evans M. J., Colledge W. H., Friedman L. S., Ponder B. A., and Venkitaraman A. R. (1998). Involvement of Brca2 in DNA repair. Molecular Cell 1, 347-357.


23. Lee H., Kim H. T., and Yun Y. (1998). Liver-specific enhancer II is the target for the p53-mediated inhibition of hepatitis B viral gene expression. J Biol Chem 273, 19786-19791.


24. Lee H., Lee Y. H. Huh Y. S., Moon H., and Yun Y. (1995). X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter. J Biol Chem 270, 31405-31412.


25. Friedman L. S., Thistlethwaite F. C., Patel K. J., Yu, V. P., Lee H., Venkitaraman, A. R., Abel K. J., Carlton M. B., Hunter S. M., Colledge W. H., et al. (1998). Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res 58, 1338-1343.


26. Kim H., Lee H., and Yun Y. (1998). X-gene product of hepatitis B virus induces apoptosis in liver cells. J Biol Chem 273, 381-385.