Person
Miller, Yury
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Biography and Research Interest
Miller’s laboratory studies inflammatory mechanisms involved in the development of atherosclerosis. A new exciting direction in our research is studying the processes of vascular inflammation in zebrafish. The optical transparency of zebrafish larvae enables monitoring vascular lipid and macrophage accumulation in real time in a live animal. This opens endless possibilities for in vivo functional studies of certain processes of atherogenesis. We are making new transgenic zebrafish for this study. A recent advance is the development of a zebrafish with conditional expression of human oxidation-specific antibody conjugated with GFP. Upon heat shock, these zebrafish express the antibody and the GFP signal is detected to monitor in vivo accumulation of oxidized lipid in the blood vessel wall.
Non-Zebrafish Publications