Biography and Research Interest

Publications

Non-Zebrafish Publications

Levenson RG. Marcu KB. On the existence of polyadenylated histone mRNA in Xenopus laevis oocytes. 1976 Oct. Cell. 9(2):311-22.

Geller R. Levenson R. Housman D. Significance of the cell cycle in commitment of murine erythroleukemia cells to erythroid differentiation. 1978 May. J Cell Physiol. 95(2):213-22.

Kane DJ. Levenson RG. Jones RF. A rapid and sensitive method for the detection of histone peptides. 1978 May. Anal Biochem. 86(1):214-9.

Levenson R. Kernen J. Housman D. Synchronization of MEL cell commitment with cordycepin. 1979 Dec. Cell. 18(4):1073-8.

Levenson R. Housman D. Memory of MEL cells to a previous exposure to inducer. 1979 Jul. Cell. 17(3):485-90.

Levenson R. Housman D. Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis. 1979 Sep. J Cell Biol. 82(3):715-25.

Housman D. Levenson R. Volloch V. Tsiftsoglou A. Gusella J. Parker D. Kernen J. Mitrani A. Weeks V. Witte O. Besmer P. Control of proliferation and differentiation in cells transformed by Friend virus. 1980. Cold Spring Harb Symp Quant Biol. 44 Pt 2,:1177-85.

Levenson R. Kernen J. Mitrani A. Housman D. DNA synthesis is not required for the commitment of murine erythroleukemia cells. 1980 Jan. Dev Biol. 74(1):224-30.

Levenson R. Housman D. Cantley L. Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment. 1980 Oct. Proc Natl Acad Sci U S A. 77(10):5948-52.

Levenson R. Housman D. Erasure of the memory response in MEL cells. 1981 Aug. Dev Biol. 86(1):81-6.

Bridges K. Levenson R. Housman D. Cantley L. Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation. 1981 Aug. J Cell Biol. 90(2):542-4.

Levenson R. Housman D. Commitment: how do cells make the decision to differentiate? 1981 Jul. Cell. 25(1):5-6.

Levenson R. Macara IG. Smith RL. Cantley L. Housman D. Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation. 1982 Apr. Cell. 28(4):855-63.

Smith RL. Macara IG. Levenson R. Housman D. Cantley L. Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. 1982 Jan 25. J Biol Chem. 257(2):773-80.

Levenson R. Macara I. Cantley L. Housman D. Ionic regulation of MEL cell commitment. 1983. J Cell Biochem. 21(1):1-8.

Levenson R. Racaniello V. Albritton L. Housman D. Molecular cloning of the mouse ouabain-resistance gene. 1984 Mar. Proc Natl Acad Sci U S A. 81(5):1489-93.

English LH. Epstein J. Cantley L. Housman D. Levenson R. Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. 1985 Jan 25. J Biol Chem. 260(2):1114-9.

Schneider JW. Mercer RW. Caplan M. Emanuel JR. Sweadner KJ. Benz EJ. Levenson R. Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. 1985 Sep. Proc Natl Acad Sci U S A. 82(18):6357-61.

Emanuel JR. Garetz S. Schneider J. Ash JF. Benz EJ. Levenson R. Amplification of DNA sequences coding for the Na,K-ATPase alpha-subunit in ouabain-resistant C+ cells. 1986 Jul. Mol Cell Biol. (7):2476-81.

Mercer RW. Schneider JW. Savitz A. Emanuel J. Benz EJ. Levenson R. Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. 1986 Nov. Mol Cell Biol. 6(11):3884-90.

Fallows D. Kent RB. Nelson DL. Emanuel JR. Levenson R. Housman DE. Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. 1987 Aug. Mol Cell Biol. 7(8):2985-7.

Kent RB. Fallows DA. Geissler E. Glaser T. Emanuel JR. Lalley PA. Levenson R. Housman DE. Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. 1987 Aug. Proc Natl Acad Sci U S A. 84(15):5369-73.

Kent RB. Emanuel JR. Ben Neriah Y. Levenson R. Housman DE. Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. 1987 Aug 21. Science. 237(4817):901-3.

Emanuel JR. Garetz S. Stone L. Levenson R. Differential expression of Na+,K+-ATPase alpha- and beta-subunit mRNAs in rat tissues and cell lines. 1987 Dec. Proc Natl Acad Sci U S A. 84(24):9030-4.

Chaudhury S. Ismail-Beigi F. Gick GG. Levenson R. Edelman IS. Effect of thyroid hormone on the abundance of Na,K-adenosine triphosphatase alpha-subunit messenger ribonucleic acid. 1987 Jan. Mol Endocrinol. 1(1):83-9.

Herrera VL. Emanuel JR. Ruiz-Opazo N. Levenson R. Nadal-Ginard B. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. 1987 Oct. J Cell Biol. 105(4):1855-65.

Schneider JW. Mercer RW. Benz EJ. Levenson R. Molecular cloning of Na+,K+-ATPase alpha subunit gene using antibody probes. 1988. Methods Enzymol. 156:379-92.

Kent RB. Fallows DA. Emanuel JR. Lalley PA. Levenson R. Housman DE. Application of gene transfer and gene mapping techniques to functional analysis of the Na,K-ATPase. 1988. Prog Clin Biol Res. 268B:97-104.

Emanuel JR. Schulz J. Zhou XM. Kent RB. Housman D. Cantley L. Levenson R. Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit. 1988 Jun 5. J Biol Chem. 263(16):7726-33.

Martin-Vasallo P. Dackowski W. Emanuel JR. Levenson R. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. 1989 Mar 15. J Biol Chem. 264(8):4613-8.

Shyjan AW. Levenson R. Antisera specific for the alpha 1, alpha 2, alpha 3, and beta subunits of the Na,K-ATPase: differential expression of alpha and beta subunits in rat tissue membranes. 1989 May 30. Biochemistry. 28(11):4531-5.

Emanuel JR. Graw S. Housman D. Levenson R. Identification of a region within the Na,K-ATPase alpha subunit that contributes to differential ouabain sensitivity. 1989 Sep. Mol Cell Biol. 9(9):3744-9.

Watson AJ. Pape C. Emanuel JR. Levenson R. Kidder GM. Expression of Na,K-ATPase alpha and beta subunit genes during preimplantation development of the mouse. 1990. Dev Genet. 11(1):41-8.

Malo D. Schurr E. Levenson R. Gros P. Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11. 1990 Apr. Genomics. 6(4):697-9.

Canfield V. Emanuel JR. Spickofsky N. Levenson R. Margolskee RF. Ouabain-resistant mutants of the rat Na,K-ATPase alpha 2 isoform identified by using an episomal expression vector. 1990 Apr. Mol Cell Biol. 10(4):1367-72.

Billecocq A. Emanuel JR. Levenson R. Baron R. 1 alpha,25-dihydroxyvitamin D3 regulates the expression of carbonic anhydrase II in nonerythroid avian bone marrow cells. 1990 Aug. Proc Natl Acad Sci U S A. 87(16):6470-4.

Shyjan AW. Ceña V. Klein DC. Levenson R. Differential expression and enzymatic properties of the Na+,K(+)-ATPase alpha 3 isoenzyme in rat pineal glands. 1990 Feb. Proc Natl Acad Sci U S A. 87(3):1178-82.

Shyjan AW. Gottardi C. Levenson R. The Na,K-ATPase beta 2 subunit is expressed in rat brain and copurifies with Na,K-ATPase activity. 1990 Mar 25. J Biol Chem. 265(9):5166-9.

Canfield VA. Okamoto CT. Chow D. Dorfman J. Gros P. Forte JG. Levenson R. Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. 1990 Nov 15. J Biol Chem. 265(32):19878-84.

Canfield VA. Okamato CT. Chow D. Dorfman J. Gros P. Forte JG. Levenson R. Identification and characterization of a gene for the H,K-ATPase beta-subunit. 1991. Soc Gen Physiol Ser. 46:89-98.

Schneider BG. Shyjan AW. Levenson R. Co-localization and polarized distribution of Na,K-ATPase alpha 3 and beta 2 subunits in photoreceptor cells. 1991 Apr. J Histochem Cytochem. 39(4):507-17.

Watts AG. Sanchez-Watts G. Emanuel JR. Levenson R. Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system. 1991 Aug 15. Proc Natl Acad Sci U S A. 88(16):7425-9.

Malo D. Schurr E. Dorfman J. Canfield V. Levenson R. Gros P. Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. 1991 Jul. Genomics. 10(3):666-72.

Shyjan AW. Canfield VA. Levenson R. Evolution of the Na,K- and H,K-ATPase beta subunit gene family: structure of the murine Na,K-ATPase beta 2 subunit gene. 1991 Oct. Genomics. 11(2):435-42.

Canfield VA. Levenson R. Structural organization and transcription of the mouse gastric H+, K(+)-ATPase beta subunit gene. 1991 Sep 15. Proc Natl Acad Sci U S A. 88(18):8247-51.

Canfield VA. Xu KY. D'Aquila T. Shyjan AW. Levenson R. Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme evolution and ouabain sensitivity. 1992 Apr. New Biol. 4(4):339-48.

Canfield VA. Levenson R. Transmembrane organization of the Na,K-ATPase determined by epitope addition. 1993 Dec 21. Biochemistry. 32(50):13782-6.

Zhou XM. Cunha MJ. Epstein J. Levenson R. Cantley LC. Cantley LG. A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. 1993 Feb 25. J Biol Chem. 268(6):4126-33.

Malo D. Gros P. Bergmann A. Trask B. Mohrenweiser HW. Canfield VA. Levenson R. Genes encoding the H,K-ATPase alpha and Na,K-ATPase alpha 3 subunits are linked on mouse chromosome 7 and human chromosome 19. 1993 Nov. Mamm Genome. 4(11):644-9.

Levenson R. Isoforms of the Na,K-ATPase: family members in search of function. 1994. Rev Physiol Biochem Pharmacol. 123:1-45.

Cameron R. Klein L. Shyjan AW. Rakic P. Levenson R. Neurons and astroglia express distinct subsets of Na,K-ATPase alpha and beta subunits. 1994 Feb. Brain Res Mol Brain Res. 21(3-4):333-43.

Liu K. Bergson C. Levenson R. Schmauss C. On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain. 1994 Nov 18. J Biol Chem. 269(46):29220-6.

Bergson C. Mrzljak L. Lidow MS. Goldman-Rakic PS. Levenson R. Characterization of subtype-specific antibodies to the human D5 dopamine receptor: studies in primate brain and transfected mammalian cells. 1995 Apr 11. Proc Natl Acad Sci U S A. 92(8):3468-72.

Kast C. Canfield V. Levenson R. Gros P. Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3. 1995 Apr 4. Biochemistry. 34(13):4402-11.

Bergson C. Mrzljak L. Smiley JF. Pappy M. Levenson R. Goldman-Rakic PS. Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain. 1995 Dec. J Neurosci. 15(12):7821-36.

Belcher SM. Zerillo CA. Levenson R. Ritchie JM. Howe JR. Cloning of a sodium channel alpha subunit from rabbit Schwann cells. 1995 Nov 21. Proc Natl Acad Sci U S A. 92(24):11034-8.

Kast C. Canfield V. Levenson R. Gros P. Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence. 1996 Apr 19. J Biol Chem. 271(16):9240-8.

Beckers MC. Ernst E. Belcher S. Howe J. Levenson R. Gros P. A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. 1996 Aug 15. Genomics. 36(1):202-5.

Canfield V. West AB. Goldenring JR. Levenson R. Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. 1996 Mar 19. Proc Natl Acad Sci U S A. 93(6):2431-5.

Mrzljak L. Bergson C. Pappy M. Huff R. Levenson R. Goldman-Rakic PS. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. 1996 May 16. Nature. 381(6579):245-8.

Canfield VA. Norbeck L. Levenson R. Localization of cytoplasmic and extracellular domains of Na,K-ATPase by epitope tag insertion. 1996 Nov 12. Biochemistry. 35(45):14165-72.

Malik N. Canfield VA. Beckers MC. Gros P. Levenson R. Identification of the mammalian Na,K-ATPase 3 subunit. 1996 Sep 13. J Biol Chem. 271(37):22754-8.

Billecocq A. Horne WC. Chakraborty M. Takeyasu K. Levenson R. Baron R. 1,25-Dihydroxyvitamin D3 selectively induces increased expression of the Na,K-ATPase beta 1 subunit in avian myelomonocytic cells without a concomitant change in Na,K-ATPase activity. 1997 Aug. J Cell Physiol. 172(2):221-9.

Lavoie L. Levenson R. Martin-Vasallo P. Klip A. The molar ratios of alpha and beta subunits of the Na+-K+-ATPase differ in distinct subcellular membranes from rat skeletal muscle. 1997 Jun 24. Biochemistry. 36(25):7726-32.

Wang SG. Eakle KA. Levenson R. Farley RA. Na+-K+-ATPase alpha-subunit containing Q905-V930 of gastric H+-K+-ATPase alpha preferentially assembles with H+-K+-ATPase beta. 1997 Mar. Am J Physiol. 272(3 Pt 1):C923-30.

Cheng XJ. Fisone G. Aizman O. Aizman R. Levenson R. Greengard P. Aperia A. PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone. 1997 Sep. Am J Physiol. 273(3 Pt 1):C893-901.

Malik N. Canfield V. Sanchez-Watts G. Watts AG. Scherer S. Beatty BG. Gros P. Levenson R. Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. 1998 Feb. Mamm Genome. 9(2):136-43.

Canfield VA. Levenson R. Domain swapping between Na,K- and H,K-ATPase identifies regions that specify Na,K-ATPase activity. 1998 May 19. Biochemistry. 37(20):7509-16.

Karpa KD. Lidow MS. Pickering MT. Levenson R. Bergson C. N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells. 1999 Nov. Mol Pharmacol. 56(5):1071-8.

Underhill DA. Canfield VA. Dahl JP. Gros P. Levenson R. The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. 1999 Nov 9. Biochemistry. 38(45):14746-51.

Dahl JP. Binda A. Canfield VA. Levenson R. Participation of Na,K-ATPase in FGF-2 secretion: rescue of ouabain-inhibitable FGF-2 secretion by ouabain-resistant Na,K-ATPase alpha subunits. 2000 Dec 5. Biochemistry. 39(48):14877-83.

Lezcano N. Mrzljak L. Eubanks S. Levenson R. Goldman-Rakic P. Bergson C. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. 2000 Mar 3. Science. 287(5458):1660-4.

Karpa KD. Lin R. Kabbani N. Levenson R. The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors. 2000 Oct. Mol Pharmacol. 58(4):677-83.

Lin R. Karpa K. Kabbani N. Goldman-Rakic P. Levenson R. Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. 2001 Apr 24. Proc Natl Acad Sci U S A. 98(9):5258-63.

Scarselli M. Novi F. Schallmach E. Lin R. Baragli A. Colzi A. Griffon N. Corsini GU. Sokoloff P. Levenson R. Vogel Z. Maggio R. D2/D3 dopamine receptor heterodimers exhibit unique functional properties. 2001 Aug 10. J Biol Chem. 276(32):30308-14.

Sweeney G. Niu W. Canfield VA. Levenson R. Klip A. Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells. 2001 Dec. Am J Physiol Cell Physiol. 281(6):C1797-803.

Lin R. Canfield V. Levenson R. Dominant negative mutants of filamin A block cell surface expression of the D2 dopamine receptor. 2002 Dec. Pharmacology. 66(4):173-81.

Albrecht PJ. Dahl JP. Stoltzfus OK. Levenson R. Levison SW. Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival. 2002 Jan. Exp Neurol. 173(1):46-62.

Kabbani N. Negyessy L. Lin R. Goldman-Rakic P. Levenson R. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. 2002 Oct 1. J Neurosci. 22(19):8476-86.

Binda AV. Kabbani N. Lin R. Levenson R. D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. 2002 Sep. Mol Pharmacol. 62(3):507-13.

Koh PO. Undie AS. Kabbani N. Levenson R. Goldman-Rakic PS. Lidow MS. Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients. 2003 Jan 7. Proc Natl Acad Sci U S A. 100(1):313-7.