Person
Voz, Marianne
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Biography and Research Interest
From zebrafish to human disease : deciphering the molecular steps of pancreas formation, regeneration and carcinogenesis.
Our laboratory is dedicated to identify molecular mechanisms controlling the generation of pancreatic cells in normal and disease state, using the zebrafish as animal model. To achieve this goal, we use a combination of transcriptomics (RNA sequencing or "RNAseq"), mutagenesis, and transgenesis and we create zebrafish models mimicking pancreatic diseases. For more informations about our project, please visit our web site http://www.giga.ulg.ac.be/zddm
Our laboratory is dedicated to identify molecular mechanisms controlling the generation of pancreatic cells in normal and disease state, using the zebrafish as animal model. To achieve this goal, we use a combination of transcriptomics (RNA sequencing or "RNAseq"), mutagenesis, and transgenesis and we create zebrafish models mimicking pancreatic diseases. For more informations about our project, please visit our web site http://www.giga.ulg.ac.be/zddm
Non-Zebrafish Publications
Kas, K., Voz, M. L., Roijer, E., Astrom, A. K., Meyen, E., Stenman, G., and Van de Ven, W. J. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet, 15: 170-174, 1997.Voz, M. L., Astrom, A. K., Kas, K., Mark, J., Stenman, G., and Van de Ven, W. J. The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. Oncogene, 16: 1409-1416., 1998.
Kas, K., Voz, M. L., Hensen, K., Meyen, E., and Van de Ven, W. J. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem, 273: 23026-23032., 1998
Astrom, A. K., Voz, M. L., Kas, K., Roijer, E., Wedell, B., Mandahl, N., Van de Ven, W., Mark, J., and Stenman, G. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Cancer Res, 59: 918-923., 1999.
Voz, M. L., Agten, N. S., Van de Ven, W. J., and Kas, K. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res, 60: 106-113., 2000
Debiec-Rychter, M., Van Valckenborgh, I., Van den Broeck, C., Hagemeijer, A., Van de Ven, W. J., Kas, K., Van Damme, B., and Voz, M. L. Histologic localization of PLAG1 in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells, Lab Invest. 81: 1289-97., 2001
Hensen, K., Van Valckenborgh, I. C., Kas, K., Van de Ven, W. J., and Voz, M. L. The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Cancer Res, 62: 1510-1517., 2002.
Voz, M.L,, Mathys J., H. K., Pendeville H, Van Valckenborgh I, Van Huffel C, Chavez M.V., Van Damme B, De Moor B, Moreau Y, Van de Ven WJM. Microarray screening for target genes of the proto-oncogene PLAG1. Oncogene, 23: 179-191, 2004.