Morpholino

MO7-cftr

ID

ZDB-MRPHLNO-190805-1

Name

MO7-cftr

Previous Names

None

Target

cftr (1)

Sequence

5' - GACACATTTTGGACACTCACACCAA - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

Splice-blocking MO.

Genome Resources

None

Target Location

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO7-cftr

No data available

Phenotype

Phenotype resulting from MO7-cftr

Phenotype	Fish	Figures
neutrophil increased amount, abnormal	i114Tg + MO7-cftr	Fig. S3 from Bernut et al., 2019

Phenotype of all Fish created by or utilizing MO7-cftr

Phenotype	Fish	Conditions	Figures
whole organism viability, ameliorated	WT + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus, viral treatment by injection: Viruses	Fig. 5. from Johansen et al., 2021
whole organism viability, exacerbated	WT + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. 5. , Fig. 6. from Johansen et al., 2021
caudal fin fin regeneration decreased occurrence, abnormal	WT + MO7-cftr	chemical treatment by environment: hydrogen peroxide, amputation: caudal fin	Figure 4 from Bernut et al., 2020
whole organism viability, ameliorated	WT + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus, viral treatment by injection: Viruses	Fig. 5. from Johansen et al., 2021
caudal fin fin regeneration decreased occurrence, abnormal	WT + MO7-cftr	amputation: caudal fin	Figure 4 from Bernut et al., 2020
whole organism viability, ameliorated	WT + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus, chemical treatment by environment: rifabutin	Fig. 6. from Johansen et al., 2021
caudal fin duox expression amount, ameliorated	WT + MO7-cftr	amputation: caudal fin	Figure 2 from Bernut et al., 2020
whole organism viability, ameliorated	WT + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus, viral treatment by injection: Viruses	Fig. 5. , Fig. 6. from Johansen et al., 2021
caudal fin fin regeneration decreased occurrence, ameliorated	WT + MO7-cftr	chemical treatment by environment: dibenziodolium chloride, amputation: caudal fin	Figure 4 from Bernut et al., 2020
caudal fin hydrogen peroxide increased amount, exacerbated	WT + MO7-cftr	amputation: caudal fin	Figure 2 from Bernut et al., 2020
whole organism viability, ameliorated	WT + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus, viral treatment by injection: Viruses, chemical treatment by environment: rifabutin	Fig. 6. from Johansen et al., 2021
neutrophil-mediated killing of bacterium decreased occurrence, abnormal	i114Tg + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. S4 from Bernut et al., 2019
neutrophil increased amount, abnormal	i114Tg + MO7-cftr	control	Fig. S3 from Bernut et al., 2019
caudal fin neutrophil apoptotic, ameliorated	i114Tg + MO7-cftr	amputation: caudal fin	Figure 3 from Bernut et al., 2020
caudal fin neutrophil increased amount, ameliorated	i114Tg + MO7-cftr	chemical treatment by environment: dibenziodolium chloride, amputation: caudal fin	Figure 2 from Bernut et al., 2020
caudal fin neutrophil increased amount, abnormal	i114Tg + MO7-cftr	amputation: caudal fin	Figure 1 , Figure 2 , Figure 5 from Bernut et al., 2020
innate immune response disrupted, abnormal	i114Tg + MO7-cftr	amputation: caudal fin	Figure 1 from Bernut et al., 2020
neutrophil chemotaxis decreased occurrence, abnormal	i114Tg + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. 4 from Bernut et al., 2019
caudal fin neutrophil increased amount, abnormal	i114Tg + MO7-cftr	chemical treatment by injection: N-formyl-L-methionyl-L-leucyl-L-phenylalanine, amputation: caudal fin	Figure 1 from Bernut et al., 2020
caudal fin neutrophil increased amount, exacerbated	i114Tg + MO7-cftr	chemical treatment by environment: hydrogen peroxide, amputation: caudal fin	Figure 2 from Bernut et al., 2020
macrophage cell death increased occurrence, abnormal	ump2Tg + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. 3 from Bernut et al., 2019
caudal fin neutrophil increased amount, exacerbated	s1999tTg; sh267Tg + MO7-cftr	amputation: caudal fin	Figure 3 from Bernut et al., 2020
whole organism decreased life span, abnormal	slc24a5^b1/b1 + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. 1 from Bernut et al., 2019
defense response to bacterium decreased efficacy, abnormal	slc24a5^b1/b1 + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. 1 from Bernut et al., 2019
whole organism cybb expression decreased amount, abnormal	slc24a5^b1/b1 + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. 6 from Bernut et al., 2019
whole organism tnfa expression increased amount, abnormal	slc24a5^b1/b1 + MO7-cftr	bacterial treatment by injection: Mycobacteroides abscessus	Fig. S7 from Bernut et al., 2019
caudal fin fin regeneration decreased occurrence, abnormal	WT + MO1-duox + MO7-cftr	amputation: caudal fin	Figure 4 from Bernut et al., 2020
caudal fin fin regeneration decreased occurrence, ameliorated	WT + MO3-csf3r + MO7-cftr	amputation: caudal fin	Figure 4 from Bernut et al., 2020
caudal fin neutrophil increased amount, ameliorated	i114Tg + MO1-duox + MO7-cftr	amputation: caudal fin	Figure 2 from Bernut et al., 2020

Citations