Morpholino

MO1-otx1

ID

ZDB-MRPHLNO-060411-1

Name

MO1-otx1

Previous Names

MO1-otx1
MO1-otx1b

Target

otx1 (1)

Sequence

5' - TAACATATAGCCTACCTGAACTCGG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

Targets the exon3/intron 3-4 junction.

Genome Resources

None

Target Location

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-otx1

Expressed Gene	Anatomy	Figures
dct	neural crest melanocyte optic cup ventral-most region	Fig. 4 from Lane et al., 2012
mitfa	neural crest cell optic cup pigmented epithelial cell	Fig. 5 from Lane et al., 2012
mitfb	epiphysis optic cup pigmented epithelial cell	Fig. 5 from Lane et al., 2012
msx3	anterior crista primordium (not) lateral crista primordium posterior crista primordium	Fig. 8 from Hammond et al., 2006

Phenotype

Phenotype resulting from MO1-otx1

Phenotype	Fish	Figures
anterior macula decreased distance posterior macula, abnormal	WIK + MO1-otx1	Fig. 8 from Hammond et al., 2006
inner ear lacks all parts of type lateral crista, abnormal	WIK + MO1-otx1	Fig. 8 from Hammond et al., 2006
inner ear lacks all parts of type lateral semicircular canal, abnormal	WIK + MO1-otx1	Fig. 8 from Hammond et al., 2006
lateral semicircular canal development disrupted, abnormal	WIK + MO1-otx1	Fig. 8 from Hammond et al., 2006

Phenotype of all Fish created by or utilizing MO1-otx1

Phenotype	Fish	Conditions	Figures
lateral semicircular canal development disrupted, abnormal	WIK + MO1-otx1	standard conditions	Fig. 8 from Hammond et al., 2006
inner ear lacks all parts of type lateral crista, abnormal	WIK + MO1-otx1	standard conditions	Fig. 8 from Hammond et al., 2006
inner ear lacks all parts of type lateral semicircular canal, abnormal	WIK + MO1-otx1	standard conditions	Fig. 8 from Hammond et al., 2006
anterior macula decreased distance posterior macula, abnormal	WIK + MO1-otx1	standard conditions	Fig. 8 from Hammond et al., 2006
retinal pigmented epithelium ventral region absent, abnormal	WT + MO1-otx1 + MO1-otx2a	standard conditions	Fig. 2 from Lane et al., 2012
retinal pigmented epithelium anterior side separated from retinal pigmented epithelium posterior side, abnormal	WT + MO1-otx1 + MO1-otx2a	standard conditions	Fig. 2 from Lane et al., 2012
eye perforate, abnormal	WT + MO1-otx1 + MO1-otx2a	standard conditions	Fig. 2 from Lane et al., 2012
optic fissure closure incomplete, abnormal	WT + MO1-otx1 + MO1-otx2a	standard conditions	Fig. 2 from Lane et al., 2012
eye perforate, abnormal	WT + MO1-otx1 + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012
optic fissure closure incomplete, abnormal	WT + MO1-otx1 + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012
retinal pigmented epithelium anterior side separated from retinal pigmented epithelium posterior side, abnormal	WT + MO1-otx1 + MO1-otx2a + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012
retinal pigmented epithelium ventral region absent, abnormal	WT + MO1-otx1 + MO1-otx2a + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012

Citations