Lab

Ninov Lab

Lab ID
ZDB-LAB-181219-1
PI / Directory
Ninov, Nikolay
Contact Person
Ninov, Nikolay
Email
nikolay.ninov@tu-dresden.de
URL
https://tu-dresden.de/cmcb/crtd/forschungsgruppen/crtd-forschungsgruppen/ninov
Address
CRTD / Center for Regenerative Therapies Dresden - Cluster of Excellence, Fetscherstraße 105 01307 Dresden
Country
Germany
Phone
+49 (0)351 458 82314
Fax
+49 351 458-82059
Line Designation
tud
Genomic Features
Statement of Research Interest
TOWARDS IN VIVO REGENERATION OF BETA-CELLS AS A FUTURE THERAPY FOR T1D

The pancreatic β-cells are the key metabolic sensors and effectors for insulin release, which is the only hormone known to lower blood glucose concentrations. Type 1 diabetes mellitus is an autoimmune disease characterized by the destruction of beta-cells in the pancreatic islets, leading to insulin deficiency and hyperglycemia. In contrast, type 2 diabetes commences with insulin resistance followed by beta cell loss and hyperglycemia. Restoring functional β-cell mass is recognized as a promising therapeutic avenue towards normalizing glycemic control in both type 1 and 2 diabetics. Thus, our research goal is to understand the molecular and cellular events required for pancreatic β-cell regeneration, and apply this knowledge towards the development of cell replacement therapies for diabetes.
Lab Members
Akhtar, Nadeem Graduate Student Delgadillo Silva, Luis Fernando Graduate Student Janjuha, Sharan Graduate Student
Kamel, Margrit Graduate Student Palme, Silvia Administrative Staff
Zebrafish Publications of lab members