Lab

Mione Lab

Lab ID
ZDB-LAB-050531-2
PI / Directory
Mione, Marina
Contact Person
Mione, Marina
Email
mariacaterina.mione@unitn.it
URL
http://www.cibio.unitn.it/465/laboratory-of-experimental-cancer-biology
Address
Department of Cellular, Computational and Integrative Biology, University of Trento Via Sommarive 9, 38123 Trento - Italy
Country
Italy
Phone
+39 0461 28 3312
Fax
+39 0461 28 3937
Line Designation
utn
Genomic Features
Statement of Research Interest
The use of the zebrafish to study cancer is an emerging field, and my laboratory has developed systems that allow to visualize oncogenic transformation of cells in different organs and tissues of transparent zebrafish larvae through the use of GFP-tagged oncogenes. Briefly, we use genetic systems for conditional and mosaic expression of oncogenes recapitulating the occurrence of somatic mutations in sporadic cancer. These systems also allow us to precisely target transformed cells with different genes to study the role of their products in transformation. Using this approach, we have studied the biology of cancer initiating cells in their native environment in models of melanoma (Santoriello et al., 2010) and glioblastoma (Mione et al., in preparation), and identified cellular and extracellular factors that allow them to thrive and establish cancer. These systems are also ideal to visualize and manipulate the early immune responses to cancer cells in a live vertebrate organism.
Lab Members
Anelli, Viviana Post-Doc Idilli, Aurora Post-Doc Precazzini, Francesca Graduate Student
Zebrafish Publications of lab members