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Fig. 2 Actigraphy of affected and healthy siblings demonstrating daily sleep arrhythmicity in individuals homozygous for the INTS1 mutated allele. Each horizontal segment of the actigraph depicts a full 24-h cycle from noon to the following noon. The height of the black lines on the chart reflects the extent and frequency of physical activity; blue and cyan depict sleep and rest time, respectively. Gray bars indicate invalid data. Actigraphs I and II of the healthy siblings (aged 10 and 8 years, respectively) show regular sleep patterns with a consistent sleep time and minor variations in waking time, while actigraphs III and IV of the affected children (aged 6 and 5 years, respectively) display several irregular sleep episodes and a substantial lack of daily rhythmicity.