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Fig. 4 The Circos plot illustrates the relationship between microbial abundance and host genotypes. The outermost ring of the plot depicts segments corresponding to various bacterial genera, with their names duly annotated. Inner bands connect these segments to a range of host genotypes, including wild-type (wt) and inducible nitric oxide synthase (iNOS) knockout, indicating the proportion of each bacterial genus present in each genotype. Adjacent to the names of the bacteria, colored bars represent the relative abundance within the respective genotypes. The breadth and color intensity of the bands are indicative of the level of association, signifying the variation in bacterial distribution across different genotypes.