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Figure 2 Zebrafish Tribbles share homology with their human and mice counterparts. (A) The gene organisation of human (orange) TRIB1, mouse (blue) Trib1, and zebrafish (red). Exon maps produced from Ensembl database. Chromosome number location (chr) and transcript sizes in kilobases (kb) are shown. (B) Comparison of the three catalytic domains of Tribbles; the pseudokinase catalytic loop and mitogen-activated protein kinase kinase (MEK)/constitutive photomorphogenic 1 (COP1) bind sites, reveals high homology between species. (C) NCBI BLAST Global align revealed a high amino acid (AA) homology between zebrafish (zf) and human Tribbles protein sequences. Values described are positives/identities. (D) Protein sizes of the first and largest protein-coding transcript of each gene are depicted in the number of AA, values obtained from Ensembl and Uniprot databases. (E–G) Protein overlays of predicted structures (AlphaFold DB) of zebrafish (coloured) and human (black) sequences.