ZFIN Image: Zang et al., 2024, Fig. 2.

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Fig. 2.

Overfed zMIR/VDBP zebrafish develop glomerular morphological changes. (A) Hematoxylin and Eosin (H&E)-stained paraffin kidney sections revealed marked glomerular hypertrophy in overfed zMIR/VDBP zebrafish. Scale bar: 10 μm. (B,C) Quantification of glomerular area (B) and average nuclear count per glomerular cross-section (C) in the four groups. At least 75 glomeruli from five fish per group were measured on three sections per fish. (D) H&E-stained sections from overfed zMIR/VDBP zebrafish showed pale cytoplasms with proximal tubule enlargement. Black arrowheads indicate the cavities in the proximal tubule, which may be caused by ectopic lipid accumulation. Scale bar: 20 μm. (E) The cross-sectional area of the proximal tubules in overfed zMIR/VDBP fish was significantly larger than that in those fed a control diet or overfed VDBP fish. At least 100 tubular cross-sections were measured in each group. Data are presented as mean±s.e.m. *P<0.05; **P<0.01; ***P<0.001; Bonferroni–Dunn multiple comparisons test.

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Acknowledgments

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