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Fig. 3 Scavenging H2O2 inhibits LATS1 activity (A) LATS1 kinase activity of immunoprecipitated LATS1 from control and Mb? cells. N = 3. (B) Cellular H2O2 levels in control, Mb?, Mb? cells with Mb overexpression and Apo-Mb overexpression; N = 3?4. (C) Representative western blot and quantification for pYAP and T-YAP levels in H9C2 cells transduced with empty vector (Ad E.V.) or with adenoviral catalase (Ad Cat) expression; N = 3. (D) LATS1 kinase activity in empty vector (Ad E.V.) or adenoviral catalase (Ad Cat) transduced H9C2 cells; N = 3. (E) Relative expression of mRNA of cardiac differentiation markers in cells overexpressing empty vector control and catalase adenovirus compared with undifferentiated cells; N = 3. Data are mean ± SEM. ?p < 0.05, ??p < 0.01.