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Fig. 3 Effect of GCSW210 on insulin sensitivity in HG-mediated insulin resistance model of zebrafish larvae. A) fluorescence imaging of glucose uptake (4.0X); B) level of glucose uptake; C) glucose level. Zebrafish larvae were exposed to d-glucose solution (130 mM) for 72 h starting 5 dpf to induce IR, followed by treatment with GCSW210 (250 μg/mL) for 24 h before determining glucose uptake. IN 100 nM was used as positive control. Data are presented as mean ± SE (n = 8) and analyzed by one-way analysis of variance. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 vs control; #p < 0.05, ##p < 0.01, ###p < 0.001 vs high glucose (HG) group. Abbreviations: IN; insulin, IR; insulin resistance.