ZFIN Image: Moriyama et al., 2016, Fig. 5

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Figure Caption

Fig. 5 3R WGD and subsequent sub/neofunctionalization of an elastin gene contributed to acquisition of BA in teleost evolution (a) Subfunctionalization and neofunctionalization of elastin genes in actinopterygian evolution. The 3R WGD duplicated elastin into elna and elnb and subfunctionalization occurred between these two genes. After duplication of these genes, mutations were accumulated in the gene body of elnb, and elnb acquired a new function for BA morphogenesis; neofunctionalization occurred. (b) Morphogenesis of BA by elnb in zebrafish heart development. Regionalization of heart such as A, V and OFT is completed by 2 dpf. At 3 dpf, elnb is expressed specifically in OFT. Cardiac progenitor cells in OFT differentiate into smooth muscle cells and elastic and smooth muscle-composed BA is generated.

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