ZFIN Image: Santhanam et al., 2023, Fig. 7

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Figure Caption

Fig. 7

Transcriptomic analysis of Horizontal and Amacrine cells in the WT-P23H integrated dataset reveals changes in axon remodeling in the RP model. A, B Horizontal cells; C–F Amacrine cells. A Violin plots showing levels of expression of canonical marker genes as well as DEGs involved in axon remodeling and microtubule stability in WT and P23H horizontal cells. B Dot plot showing the specific enrichment of cx52.6, cx52.9, and cx55.5 in horizontal cell cluster (9) compared to all other retinal cell types. C Our data identified six different types of amacrine clusters (1, 5, 11, 19, 21, and 22). Violin plots showing levels of expression of canonical marker genes expressed in different amacrine clusters. D–F Violin plots showing levels of expression of DEGs involved in glutamate signaling (D), oxidative stress response (E), and neuron projection guidance (F) between WT and P23H amacrine cells

Acknowledgments

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