ZFIN Image: Maili et al., 2023, FIGURE 4

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FIGURE 4

Perturbation of fos causes bone, cartilage, and tooth abnormalities. (A–D) Fos crispants (16/19) and morphants (61/62) show abnormally shaped jaw cartilages, including a smaller ethmoid plate, Meckel’s and palatoquadrate cartilages, missing basibranchial cartilages (B–C’) red arrows) and missing pharyngeal teeth (red asterisks). (E–H) Only 24% of fos crispant and morphant zebrafish showed mineralization at the fifth ceratobranchial arch (F, G), white arrows) compared to 100% of the UIC/MM (E and H). Tooth number was reduced, and tooth shape/size was altered in fos crispants and morphants compared to UIC/MM (E–H), white asterisks). UIC, uninjected control; F0, crispant; MO, morpholino; MM, mismatch.

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Acknowledgments

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