ZFIN Image: Shi et al., 2023, Figure 6

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Figure 6

Deficiency of chd7 lowered the quality of myelin sheath. (a) Transmission electron micrograph of the axons of Mauthner cells in the WT and KO groups of 5 dpf zebrafish larvae. Scale bars: 500 nm. (b) Transmission electron micrograph of other ventral axons in the WT and KO groups of 5 dpf zebrafish larvae, with yellow arrows indicating myelinated axons and red arrows indicating unmyelinated axons. Scale bars: 2 μm. (c,d) Myelin thickness analysis of Mauthner cells and other ventral axons. Compared with the WT group, both Mauthner cells and other ventral axons in the KO group had a higher ratio, implying thinner myelin sheaths. Data shown as mean ± sem. unpaired Student’s two-tailed t-test, * p < 0.05, **** p < 0.0001.

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Acknowledgments

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