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Fig. 9
Shh signaling inhibitor HPI-1 rescues the blowout coloboma phenotype in rerea mutant zebrafish embryos. Treatment of rerea mutant zebrafish embryos with HPI-1 (5 μM) reduces the occurrence of coloboma phenotype from 71.3% to 26.3% (Student's t test, P < .05) coloboma in homozygous mutant embryos.
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