ZFIN Image: Fetsko et al., 2022, Fig. 2

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Figure Caption

Fig. 2

Fig. 2. Identification of zebrafish uw112 as a new mutant allele of kdrl. (A) Representative confocal images (dorsal views; anterior left) of the complementation test between uw112 and kdrl^um19 mutants showing the same mutant phenotype as the uw112 mutants at 3 dpf. Scale bar is 100 μm. (B) DNA sequence for segments of kdrl^WT and mutant kdrl^uw112 showing the T41A mutation (circled). The N-terminal protein sequence is also provided, showing the L14H protein mutation (highlighted). (C) SignalP-5.0 graphs predicting the presence of a signal peptide in the WT Kdrl protein verses the mutant Kdrl.

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 494, Fetsko, A.R., Sebo, D.J., Taylor, M.R., Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis, 46-59, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.