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Figure 9
Chord diagram obtained from Spearman’s correlation analysis showing the relationship between social withdrawal and anxiety-like behavior, excitation/inhibition imbalance and excessive IL-1β expression. Links indicate strong positive (+) and negative (−) significant correlations, with “r” values above 0.6 or below −0.6, respectively. Notice that glutamatergic dysfunction was associated with social withdrawal behavior whereas GABAergic and endocannabinoid system dysfunction was associated with increased anxiety. Excessive IL-1β expression in Dm was associated with anxiety-like behavior while in PM and SRF was linked both to social withdrawal and increased anxiety. p ≤ 0.05.