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Figure 2
Luciferase reporter gene assay validates Hif1α targeting foxO4. (A) A schematic depiction of the foxO4 promoter region containing two putative Hif1α binding sites. Underlined letters indicate hypoxia response element sequence. Black boxes indicate sites. Blank boxes indicate disrupted sites. (B) Luciferase reporter assay for foxO4 promoter constructs. NS: Not significant. * p < 0.05.
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