ZFIN Image: Keatinge et al., 2023, Fig. 4.

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Figure Caption

Fig. 4.

Gaucher cell accumulation in the retina of gba1^−/−;smpd1^−/− double mutants. (A) Analysis of the numbers of 4C4-positive cells within the retina revealed comparatively significant increases of ∼50% in both gba1^−/− (P=0.0026) and gba1^−/−;smpd1^−/− mutants (P=0.0193) compared to those in WT, despite enhancement of key glycolipid levels in the double mutants. 4C4-positive cell counts in smpd1^−/− were not statistically different to those in WT. Data represented are the mean±s.d. *P<0.05; **P<0.01 (two-way ANOVA). n= 4 for all groups. (B) 4C4-positive cells in the retina of the gba1^−/− and gba1^−/−;smpd1^−/− double mutants were localised throughout the retina and appeared larger and rounder (arrows) compared to ramified WT 4C4-positive cells (arrowheads). Scale bar: 50 μm.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.