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Fig. 9
SMN and TGS1 protect against neurodegeneration through both common and specific routes. (A) Roles of SMN and TGS1 in snRNA biogenesis. The dashed arrow line indicates that the role of TGS1 in 3′-end processing could be indirect. (B) A model for the roles of TGS1 and SMN in prevention of neurodegeneration. The effects of TGS1 or SMN deficiency on snRNA biogenesis and general transcription suggest that these proteins play interconnected roles in prevention of neurodegeneration.
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Full text @ Nucleic Acids Res.