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Fig. 9 Fig. 9. The role of Nox4 in early skeletal development of zebrafish. In nox4−/− zebrafish, TGF-β/p-Smad2 signaling decreases, leading to decreased expression of the osteogenic differentiation-related genes RUNX2, OSX, and OCN in osteoblasts. This may be one reason for osteogenic defects in nox4−/− zebrafish.
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Reprinted from Free radical biology & medicine, 193(Pt 2), Cao, Z., Liu, G., Zhang, H., Wang, M., Xu, Y., Nox4 promotes osteoblast differentiation through TGF-beta signal pathway, 595-609, Copyright (2022) with permission from Elsevier. Full text @ Free Radic. Biol. Med.