ZFIN Image: Liang et al., 2023, Figure 5

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Figure 5

Knockdown of p53 and inhibition of jak2 partially rescue malformation and anemia in nop56 mutants. (A) WISH analysis of p53 in siblings and mutants. (B) qRT-PCR showed that p53 expression was increased significantly in nop56 mutants. qRT-PCR was performed with biological repeats and technical repeats in triplicate. n = 3, * p < 0.05. (C) Analyses of the phenotype and hemoglobin level after p53 knockdown and CEP-33779 treatment in nop56 mutants. Knockdown of p53 partially rescued the morphological malformations, but not anemia, at 48 hpf. However, CEP-33779 partially rescued the anemic phenotype, but not malformations, at 48 hpf. Arrowhead indicates erythroid cells. All scale bars represent 1 mm.

Acknowledgments

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