ZFIN Image: Tan et al., 2022, Fig. 1

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Fig. 1 Early responses to modulation of Wnt and Fgf. (A–J) Dorsal views (anterior to the top) showing expression at 14 hpf of the artificial Wnt reporter top:gfp (A–E) and the Fgf-target gene etv5b (F–J) following treatment at 12 hpf with DMSO (control), hs:dkk1 (39 °C for 1 h) + 10 μM IWR-1 added immediately after heat shock, BIO (5 μM), SU5402 (70 μM), or hs:fgf8a (39 °C for 1 h). Epiphysis (epi) and midbrain-hindbrain border (MHB) are indicated. Brackets mark a zone of weaker top:gfp expression in the hindbrain. The same conditions were used in subsequent figures, except for changes in treatment duration and time of fixation as noted.

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Acknowledgments

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Reprinted from Developmental Biology, 492, Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B., Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear, 139-153, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.