Figure 5

Mutants with increased axial length show a myopic shift in refractive status. Refractive status measured by eccentric photorefraction. The lama2, lrrc4c, kcnq5 mutants showed a myopic shift in refractive status at 2mpf (lama2 mutant: effect size = − 1.4D, p = 0.018; lrrc4c mutant: effect size = − 3.4D, p < 0.0001; kcnq5 mutant: effect size = − 2.4D, p = 0.003) and 4mpf (lama2 mutant: effect size = − 2.0D, p < 0.0001; lrrc4c mutant: effect size = − 1.2D, p = 0.003; kcnq5 mutant : effect size = − 2.6D, p < 0.0001), relative to WT (n = 20 eyes per timepoint). The tjp2 mutant showed a hyperopic shift at 4mpf (effect size = + 2.1D, p = 0.001). See Supplementary Data ^S5 for all data. Error bars: SEM. Significance: ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001. Mpf: months post-fertilization, WT: wild-type, tjp2 mutant: tjp2a^b1367tjp2b^b1368, pde11a mutant: pde11a^re13pde11a-like^re14, shisa6 mutant: shisa6^re15, lama2 mutant: lama2^re16, lrrc4c mutant: lrrc4ca^re17lrrc4cb^re18, kcnq5 mutant: kcnq5a^re19kcnq5b^re20, SEM: Standard error of the mean.